Regulation of hypoxia-inducible factor 1α is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway
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Summary
The identification of an oxygen-dependent degradation (ODD) domain within HIF-1α that controls its degradation by the ubiquitin-proteasome pathway is reported, which may provide a means of controlling gene expression by changes in oxygen tension.
- Type
- article
- Published
- 1998-07-07
- Cited by
- 2,157
- References
- 38
- Access
- Open access
- OpenAlex
- https://openalex.org/W2075054245
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:10454425
Keywords
Transactivation, Ubiquitin, Proteasome, Hypoxia-inducible factors, PAS domain
References
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- Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit*
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- PAS is a dimerization domain common to Drosophila Period and several transcription factors
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- Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules.
Cited by
- Genetic modulation of hypoxia induced gene expression and angiogenesis: relevance to brain tumors.
- Characterization of the Role of Mitochondrial Function During Tumor Development and Muscle Wasting
- Role of hypoxia and hypoxia inducible factors (HIFs) in cells of Ewing’s Sarcoma Family Tumors
- A new biological strategy for high productivity of recombinant proteins in animal cells by the use of hypoxia-response enhancer.
- Cadmium blocks hypoxia-inducible factor (HIF)-1-mediated response to hypoxia by stimulating the proteasome-dependent degradation of HIF-1alpha.
- Regulation of transcription factors by protein degradation
- Oxygen Sensing and HIF-1 Activation Does Not Require an Active Mitochondrial Respiratory Chain Electron-transfer Pathway*
- Hypoxia Regulation of Gene Transcription
- Mechanism, origin, and evolution of anoxia tolerance in animals.
- Adriana and Luisa Castellucci Award lecture 2001. Hypoxia inducible factor-1: oxygen regulation of trophoblast differentiation in normal and pre-eclamptic pregnancies--a review.
- Role of nitric oxide in the regulation of HIF-1α expression during hypoxia
- Signal transduction to hypoxia-inducible factor 1.
- Hypoxia Activates Multiple Transcriptional Pathways in Mouse Pheochromocytoma Cells
- HIF-1: Using Two Hands to Flip the Angiogenic Switch
- Hypoxia and hypoxia inducible factors (HIF) as important regulators of tumor physiology.
- Hypoxia-inducible factor 1-related diseases and prospective therapeutic tools.
- Cell cycle kinase inhibitor expression and hypoxia-induced cell cycle arrest in human cancer cell lines.
- Roles of SCF and VHL ubiquitin ligases in regulation of cell growth.
- Regulation of the prolyl hydroxylase domain protein 2 (phd2/egln-1) gene: identification of a functional hypoxia-responsive element.
- Regulation of hypoxia-inducible factor (HIF)-1 activity and expression of HIF hydroxylases in response to insulin-like growth factor I.
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