Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death
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Summary
Cyclophilin D and the mitochondrial permeability transition are required for mediating Ca2+- and oxidative damage-induced cell death, but not Bcl-2 family member-regulated death.
- Type
- article
- Published
- 2005-03-31
- Cited by
- 2,342
- References
- 28
- OpenAlex
- https://openalex.org/W2074800090
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4418460
Keywords
Mitochondrial permeability transition pore, Programmed cell death, Mitochondrion, Cell biology, Voltage-dependent anion channel
References
- Isolation and subfractionation of mitochondria from animal cells and tissue culture lines.
- Mitochondrial non-specific pores remain closed during cardiac ischaemia, but open upon reperfusion.
- Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC
- Contribution of the mitochondrial permeability transition to lethal injury after exposure of hepatocytes to t-butylhydroperoxide.
- The Mitochondrial Permeability Transition, Release of Cytochrome c and Cell Death
- Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria.
- The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore
- Protection by Cyclosporin A of ischemia/reperfusion-induced damage in isolated rat hearts.
- Bid acts on the permeability transition pore complex to induce apoptosis
- Regulated and unregulated mitochondrial permeability transition pores: a new paradigm of pore structure and function?
- A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis.
- On the involvement of mitochondrial intermembrane junctional complexes in apoptosis.
- Preservation of Mitochondrial Structure and Function after Bid- or Bax-Mediated Cytochrome c Release
- Mitochondrial Targeted Cyclophilin D Protects Cells from Cell Death by Peptidyl Prolyl Isomerization*
- The permeability transition pore complex: another view.
- Bax-induced Cytochrome C Release from Mitochondria Is Independent of the Permeability Transition Pore but Highly Dependent on Mg2+ Ions
- Cyclophilin-D promotes the mitochondrial permeability transition but has opposite effects on apoptosis and necrosis.
- Sanglifehrin A Acts as a Potent Inhibitor of the Mitochondrial Permeability Transition and Reperfusion Injury of the Heart by Binding to Cyclophilin-D at a Different Site from Cyclosporin A*
- Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD‐specific caspase activation and independently of mitochondrial transmembrane depolarization
- Mitochondrial permeability: Dual role for the ADP/ATP translocator?
Cited by
- Improving cardioprotection during cardiac bypass surgery
- Mitochondrial DNA Mutations, Apoptosis, and the Misfolded Protein Response
- Suppression of Apoptosis by Cyclophilin D via Stabilization of Hexokinase II Mitochondrial Binding in Cancer Cells*
- Preconditioning and postconditioning: united at reperfusion.
- The Isopeptidase Inhibitor G5 Triggers a Caspase-independent Necrotic Death in Cells Resistant to Apoptosis
- Mitochondrial Ca(2+) as a key regulator of mitochondrial activities.
- Role of sarcoplasmic reticulum in mitochondrial permeability transition and cardiomyocyte death during reperfusion.
- Ubiquinone Analogs: A Mitochondrial Permeability Transition Pore-Dependent Pathway to Selective Cell Death
- Protective Role of Transient Pore Openings in Calcium Handling by Cardiac Mitochondria*
- Mitochondrial permeability transition
- Mitochondrial Control of Cellular Life, Stress, and Death
- Mitochondrial calcium and reactive oxygen species regulate agonist-initiated platelet phosphatidylserine exposure
- Central role of mitochondrial injury in the pathogenesis of acute pancreatitis
- Where killers meet--permeabilization of the outer mitochondrial membrane during apoptosis.
- Necroptosis in health and diseases.
- Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles’ heel?
- Cyclophilin D regulates mitochondrial flashes and metabolism in cardiac myocytes.
- Cyclosporin A protects against Lead neurotoxicity through inhibiting mitochondrial permeability transition pore opening in nerve cells.
- VDAC in cancer.
- Desensitizing Mitochondrial Permeability Transition by ERK-Cyclophilin D Axis Contributes to the Neuroprotective Effect of Gallic Acid against Cerebral Ischemia/Reperfusion Injury
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- Role of the mitochondrial membrane permeability transition in cell death
- Mitochondrial membrane permeability transition and cell death.
- The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore
- Cyclophilin-D promotes the mitochondrial permeability transition but has opposite effects on apoptosis and necrosis.