Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron
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Summary
This finding represents a new component of the innate immune system and the acute phase response to infection and limits bacterial growth by sequestrating the iron-laden siderophore.
- Type
- article
- Published
- 2004-12-16
- Cited by
- 1,818
- References
- 46
- OpenAlex
- https://openalex.org/W2074692187
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4422697
Keywords
Siderophore, Lipocalin, Innate immune system, Immune system, Ferritin
References
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- Degenerate oligonucleotide-primed PCR: general amplification of target DNA by a single degenerate primer.
- A 25 kDa α2‐microglobulin‐related protein is a component of the 125 kDa form of human gelatinase
- Lipocalins as biochemical markers of disease.
- Microbial siderophore-mediated transport.
- Human neutrophil gelatinase-associated lipocalin and homologous proteins in rat and mouse.
- Identification of a New Acute Phase Protein (*)
- The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors.
- Z and W chromosomes of chickens: studies on their gene functions in sex determination and sex differentiation
- The monotreme genome: a patchwork of reptile, mammal and unique features?
- The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition.
- Toll-like receptors.
- Mouse oncogene protein 24p3 is a member of the lipocalin protein family.
- Unusual sex chromosome inheritance in mammals.
Cited by
- Isolation of a siderophore produced by methicillin-resistant Staphylococcus aureus strain H372
- Neutrophil gelatinase-associated lipocalin as a survival factor.
- mRNA expression in mouse hypothalamus and basal forebrain during influenza infection: a novel model for sleep regulation.
- Interleukin-8 Secretion in Response to Aferric Enterobactin Is Potentiated by Siderocalin
- The C/EBPβ Isoform 34-kDa LAP Is Responsible for NF-IL-6-Mediated Gene Induction in Activated Macrophages, but Is Not Essential for Intracellular Bacteria Killing1
- Inhibition of lipocalin 2 impairs breast tumorigenesis and metastasis.
- Neutrophil gelatinase-associated lipocalin as a biomarker of acute kidney injury--where do we stand today?
- Investigating the role of lipocalin-2 as a diagnostic indicator for nonalcoholic steatohepatitis in a fructose-induced rat fatty liver model: First experimental studies
- Immunoassays distinguishing between HNL/NGAL released in urine from kidney epithelial cells and neutrophils.
- The association of serum lipocalin-2 levels with metabolic and clinical parameters in obese children: a pilot study
- Enterobactin-Mediated Delivery of β-Lactam Antibiotics Enhances Antibacterial Activity against Pathogenic Escherichia coli
- Lag phase-associated iron accumulation is likely a microbial counter-strategy to host iron sequestration: role of the ferric uptake regulator (fur).
- Metachelins, mannosylated and N-oxidized coprogen-type siderophores from Metarhizium robertsii.
- Neutrophil gelatinase-associated lipocalin (NGAL) and insulin-like growth factor (IGF)-1 association with a Mannheimia haemolytica infection in sheep.
- Lipocalin-2 enhances angiogenesis in rat brain endothelial cells via reactive oxygen species and iron-dependent mechanisms
- Group B streptococcus alters properties of vaginal epithelial cells in pregnant women.
- Tumour stroma‐derived lipocalin‐2 promotes breast cancer metastasis
- Human Metabolome-derived Cofactors Are Required for the Antibacterial Activity of Siderocalin in Urine
- Lipocalin-2 protects the brain during inflammatory conditions
- Citrobacter rodentium: A Model Enteropathogen for Understanding the Interplay of Innate and Adaptive Components of Type 3 Immunity
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