Initiation and Synergistic Fibrillization of Tau and Alpha-Synuclein
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Summary
Interactions between α-syn and tau can promote their fibrillization and drive the formation of pathological inclusions in human neurodegenerative diseases.
- Type
- article
- Published
- 2003-04-25
- Cited by
- 909
- References
- 24
- OpenAlex
- https://openalex.org/W2073893553
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:20223000
Keywords
Alpha-synuclein, Alpha (finance), Amyloid (mycology), Fibril, Genetically modified mouse
References
- Chaperone‐like activity of synucleins
- Neuropathology of synuclein aggregates
- Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein
- Synaptic Vesicle Depletion Correlates with Attenuated Synaptic Responses to Prolonged Repetitive Stimulation in Mice Lacking α-Synuclein
- Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17
- Structural studies of tau protein and Alzheimer paired helical filaments show no evidence for beta-structure.
- Tau protein isoforms, phosphorylation and role in neurodegenerative disorders.
- Accelerated in vitro fibril formation by a mutant α-synuclein linked to early-onset Parkinson disease
- Functional implications for the microtubule-associated protein tau: Localization in oligodendrocytes
- Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans
- Polymerization of tau peptides into fibrillar structures. The effect of FTDP‐17 mutations
- Accelerated filament formation from tau protein with specific FTDP‐17 missense mutations
- Mutant and Wild Type Human α-Synucleins Assemble into Elongated Filaments with Distinct Morphologies in Vitro *
- α-Synuclein Binds to Tau and Stimulates the Protein Kinase A-catalyzed Tau Phosphorylation of Serine Residues 262 and 356*
- NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded.
- alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease.
- The Lewy body variant of Alzheimer's disease
- A nucleated assembly mechanism of Alzheimer paired helical filaments.
- Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB)
- Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease.
Cited by
- Exosomes-associated neurodegeneration and progression of Parkinson's disease.
- Interactions of amyloidogenic proteins
- Molecular Pathways of Neurodegeneration in Parkinson's Disease
- Template-assisted filament growth by parallel stacking of tau.
- Mutations causing neurodegenerative tauopathies.
- The gene expression profile of extraskeletal myxoid chondrosarcoma
- Silver stainings distinguish Lewy bodies and glial cytoplasmic inclusions: comparison between Gallyas-Braak and Campbell-Switzer methods
- A critical reappraisal of current staging of Lewy-related pathology in human brain
- Immunomodulation Targeting Abnormal Protein Conformation Reduces Pathology in a Mouse Model of Alzheimer's Disease
- Protein Partners of α‐Synuclein in Health and Disease
- Cognitive and Pathological Influences of Tau Pathology in Lewy Body Disorders
- Diversity of pathological features other than Lewy bodies in familial Parkinson's disease due to SNCA mutations.
- α-Synuclein aggregation and modulating factors.
- Morphological substrates of parkinsonism with and without dementia: a retrospective clinico-pathological study.
- Soluble alpha-synuclein oligomers are associated with reduced synapsin expression and enhanced cognitive decline in Alzheimer's disease
- The Impact of Genetic Research on Our Understanding of Parkinson’s Disease
- Interaction between α-synuclein and tau in Parkinson's disease comment on Wills et al.: elevated tauopathy and α-synuclein pathology in postmortem Parkinson's disease brains with and without dementia. Exp Neurol 2010; 225: 210-218.
- The role of inclusions in ALS pathogenesis
- Two Studies on Parkinson’s Disease Protein, α-Synuclein: Amino Acid Determinants and Truncations
- ASYN and tau interaction : new drug target for neurodegenerative diseases
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