A Simple Cipher Governs DNA Recognition by TAL Effectors
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Summary
It is shown that a repeat-variable pair of residues specifies the nucleotides in the target site, one pair to one nucleotide, with no apparent context dependence, which represents a previously unknown mechanism for protein-DNA recognition that explains TAL effector specificity, enables target site prediction, and opens prospects for use of TAL effects in research and biotechnology.
- Type
- article
- Published
- 2009-12-11
- Cited by
- 1,984
- References
- 8
- OpenAlex
- https://openalex.org/W2073873559
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:6648530
Keywords
Effector, Hypervariable region, Biology, DNA, Genetics
References
- A Bacterial Effector Acts as a Plant Transcription Factor and Induces a Cell Size Regulator
- Gene-for-gene-mediated recognition of nuclear-targeted AvrBs3-like bacterial effector proteins.
- Plant Pathogen Recognition Mediated by Promoter Activation of the Pepper Bs3 Resistance Gene
- R gene expression induced by a type-III effector triggers disease resistance in rice
- Os8N3 is a host disease-susceptibility gene for bacterial blight of rice
- Characterization of AvrHah1, a novel AvrBs3-like effector from Xanthomonas gardneri with virulence and avirulence activity.
Cited by
- DNA hydrolysis and genome editing applications of GIY-YIG family homing endonucleases
- Functional domains and motifs of bacterial type III effector proteins and their roles in infection.
- Quantitative and Qualitative Stem Rust Resistance Factors in Barley Are Associated with Transcriptional Suppression of Defense Regulons
- TALENs: a widely applicable technology for targeted genome editing
- TAL effectors: highly adaptable phytobacterial virulence factors and readily engineered DNA targeting proteins
- Live visualization of chromatin dynamics with fluorescent TALEs
- Nanomedicine: Tiny Particles and Machines Give Huge Gains
- Engineered TAL Effector modulators for the large-scale gain-of-function screening
- Expansion of the CRISPR-Cas9 genome targeting space through the use of H1 promoter-expressed guide–RNAs
- A multicolor panel of TALE-KRAB based transcriptional repressor vectors enabling knockdown of multiple gene targets
- Molecular scissors and their application in genetically modified farm animals
- TALEN-mediated targeted mutagenesis produces a large variety of heritable mutations in rice.
- MitoTALEN: A General Approach to Reduce Mutant mtDNA Loads and Restore Oxidative Phosphorylation Function in Mitochondrial Diseases.
- The Development of TALE Nucleases for Biotechnology
- Reactivation of Latent HIV-1 Expression by Engineered TALE Transcription Factors
- Quantification of dopaminergic neuron differentiation and neurotoxicity via a genetic reporter
- Next-generation mammalian genetics toward organism-level systems biology
- A Transcription Activator-Like Effector Tal7 of Xanthomonas oryzae pv. oryzicola Activates Rice Gene Os09g29100 to Suppress Rice Immunity
- CRISPR/Cas9 Technology: Applications and Human Disease Modeling.
- Brain organoids and the study of neurodevelopment
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