Long term potentiation is accompanied by a reduction in dendritic responsiveness to glutamic acid
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Summary
The studies reported here represent an attempt to analyse the mechanisms underlying physiological plasticity in the hippocampus, in particular the locus and anatomical specificity of the effect, and the effects of glutamic acid applied iontophoretically to different levels of the dendritic trees of the pyramidal cells before and after potentiation of the extracellular postsynaptic response.
- Type
- article
- Published
- 1976-09-09
- Cited by
- 86
- References
- 9
- OpenAlex
- https://openalex.org/W2073813081
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4156796
Keywords
Long-term potentiation, Neuroscience, Postsynaptic potential, Synaptic plasticity, Stimulation
References
- Chemical Nature of Synaptic Transmission in Vertebrates
- Iontophoretic studies of neurones in the mammalian cerebral cortex
- Motor end‐plate ‘desensitization’ by repetitive nerve stimuli
- Long-term potentiation of the perforant path-granule cell synapse in the rat hippocampus.
- Long‐lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path
- GDEE antagonism of iontophoretic amino acid excitations in the intact hippocampus and in the hippocampal slice preparation.
- Long-lasting facilitation of a synaptic potential following tetanization in the in vitro hippocampal slice.
- Long lasting changes in the spontaneous activity of hippocampal neurons following stimulation of the entorhinal cortex.
- The chemical excitation of spinal neurones by certain acidic amino acids
Cited by
- Neuroplasticity in the hippocampal formation.
- The modulation of neurotransmitter release at synaptic junctions.
- Glutamate, Cell Death and Memory
- Plasticité de la dynamique spatiale et temporelle de la représentation d’une odeur dans le bulbe olfactif de souris
- Mechanisms of synaptic modulation.
- Long-lasting facilitation of synaptic transmission.
- Posttranslational regulation of ionotropic glutamate receptors and synaptic plasticity.
- GABAA receptors control the excitability of neuronal populations.
- Synaptic plasticity at archicortical and neocortical levels
- Reevaluating the constraints on hypotheses regarding LTP expression
- Long-term potentiation in the hippocampus.
- Novel expression mechanism for synaptic potentiation: alignment of presynaptic release site and postsynaptic receptor.
- Evoked potentials and long-term potentiation in the mouse dentate gyrus after stimulation of the entorhinal cortex.
- Short lasting changes in hippocampal neuronal excitability following repetitive synaptic activation.
- Long‐term potentiation and depression of synaptic responses in the rat hippocampus: localization and frequency dependency.
- Precisely localized LTD in the neocortex revealed by infrared-guided laser stimulation.
- Stimulation-dependent uptake of glutamic acid by hippocampal slices.
- The role of protein kinase C in long-term potentiation: a testable model.
- Long-term potentiation of hippocampal synaptic transmission affects rate of behavioral learning.
- A model of imprinting evolved from neurophysiological concepts.
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