Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract?
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Summary
It is argued that the increasing incidence of reproductive abnormalities in the human male may be related to increased oestrogen exposure in utero, and mechanisms by which this exposure could occur are identified.
- Type
- article
- Published
- 1993-05-29
- Cited by
- 1,913
- References
- 32
- OpenAlex
- https://openalex.org/W2073264207
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:33135527
Keywords
Diethylstilbestrol, Pregnancy, In utero, Physiology, Incidence (geometry)
References
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- Proliferation of Sertoli cells during development of the human testis assessed by stereological methods.
- Diet, Breast Cancer, and Sex Hormone Metabolism
- Declining sperm counts in men--is there an endocrine cause?
- Diethylstilbestrol and estradiol binding to serum albumin and pregnancy plasma of rat and human.
- The effect of in utero ethinyl oestradiol exposure on the risk of cryptorchid testis and testicular teratoma in mice.
- Reproductive and general metabolic effects of phytoestrogens in mammals.
- Gonadal dysgenesis induced by prenatal exposure to ethinyl estradiol in mice.
- Early postnatal exposure to PCBs: Sperm function in rats
- Evidence for decreasing quality of semen during past 50 years.
- Determination of the elongate spermatid-Sertoli cell ratio in various mammals.
- Diverging trends in incidence and mortality of testicular cancer in Denmark, 1943-1982.
- Mullerian inhibiting substance ontogeny and its modulation by follicle-stimulating hormone in the rat testes.
- Abnormal sexual development in transgenic mice chronically expressing Müllerian inhibiting substance
- Reproductive Effects of Environmental Agents
- Mullerian inhibiting substance messenger ribonucleic acid expression in granulosa and Sertoli cells coincides with their mitotic activity.
Cited by
- Characterization of G protein-coupled estrogen receptor (GPER) in breast epithelial proliferation and morphogenesis
- Have sperm counts been reduced 50 percent in 50 years? A statistical model revisited.
- Cancer risk in fathers and brothers of testicular cancer patients in Denmark. A population‐based study
- Abnormal sperm morphology and function in the fathers of hypospadiacs.
- Epidemiological analysis of persistent organochlorine contaminants in cetaceans.
- Polymorphism in the cytochrome P450 2E1 gene and alcohol-induced disorders of human spermatogenesis.
- Developing a Laboratory Animal Model for Perinatal Endocrine Disruption: The Hamster Chronicles
- Neonatal exposure of male rats to estradiol benzoate causes rete testis dilation and backflow impairment of spermatogenesis
- Comparative estrogenic activity of wine extracts and organochlorine pesticide residues in food.
- Parental exposure, adverse pregnancy and offspring effects--perspectives in developmental epidemiology.
- Prenatal exposures and long-term health effects.
- In vitro tests for essential sperm functions using the phyto‐oestrogen genistein as a test substance*
- Développementin vitro de la lignée germinale foetale mâle chez le rat, la souris et l’homme
- Maternal exposure to a low dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) suppressed the development of reproductive organs of male rats: dose-dependent increase of mRNA levels of 5alpha-reductase type 2 in contrast to decrease of androgen receptor in the pubertal ventral prostate.
- Lethal dose and reproductive parameters of p-nonylphenol in rats.
- Receptor‐mediated ethinylestradiol‐induced oxidative DNA damage in rat testicular cells
- Sexual maturation in relation to polychlorinated aromatic hydrocarbons: Sharpe and Skakkebaek's hypothesis revisited.
- Exposure to genistein during gestation and lactation demasculinizes the reproductive system in rats.
- Effects of Genistein Isoflavone (4′,5′,7-Trihydroxyisoflavone) and Dexamethasone on Functional Characteristics of Spermatozoa
- Biology and epidemiology of testicular dysgenesis syndrome
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