Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite.
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Summary
A dose threshold exists for bromobenzene-induced hepatic necrosis and it is demonstrated that the hepatotoxic metabolite is preferentially conjugated (detoxified) with glutathione, thereby depleting glutATHione from the liver.
- Type
- article
- Published
- 1974-01-01
- Cited by
- 3,372
- References
- 0
- OpenAlex
- https://openalex.org/W2073092594
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:46753054
Keywords
Bromobenzene, Glutathione, Metabolite, Chemistry, In vivo
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