Acidic Mammalian Chitinase in Asthmatic Th2 Inflammation and IL-13 Pathway Activation
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Summary
It is shown that acidic mammalian chitinase (AMCase) is induced via a T helper-2 (Th2)–specific, interleukin-13 (IL-13)–mediated pathway in epithelial cells and macrophages in an aeroallergen asthma model and expressed in exaggerated quantities in human asthma.
- Type
- article
- Published
- 2004-06-11
- Cited by
- 854
- References
- 18
- OpenAlex
- https://openalex.org/W2072705074
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:19486575
Keywords
Chitinase, Aeroallergen, Chemokine, Mediator, Asthma
References
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- Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis.
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- Knockout of the Rodent Malaria Parasite Chitinase PbCHT1 Reduces Infectivity to Mosquitoes
- Inhibitors of chitinases.
- Chitinases of human parasites and their implications as antiparasitic targets.
Cited by
- Whipple disease: intestinal infiltrating cells exhibit a transcriptional pattern of M2/alternatively activated macrophages.
- Effect of carbon dioxide on neonatal mouse lung: a genomic approach.
- Glycogen synthase kinase-3beta inhibition attenuates asthma in mice.
- Evolution of Mammalian Chitinase(-Like) Members of Family 18 Glycosyl Hydrolases
- Gene expression profiling of experimental asthma reveals a possible role of paraoxonase-1 in the disease.
- Acidic Mammalian Chitinase Negatively Affects Immune Responses during Acute and Chronic Aspergillus fumigatus Exposure
- Comparative models of transplant and non-transplant human kidney disease
- Genome-Wide Association Studies: Progress in Identifying Genetic Biomarkers in Common, Complex Diseases
- Linking inflammation reactions to cancer: novel targets for therapeutic strategies.
- Eosinophil as a target for pathophysiological factors and pharmacological compounds
- Novel Mechanisms In Dendritic Cells That Promote Th2 and Th17 But Not Th1 Responses In The Lung
- The Characterization of Chitin Microparticle Preparations: Degree of Acetylation and its Effect on Immunologic Response
- Chitinase Inhibitor Allosamidin Is a Signal Molecule for Chitinase Production in Its Producing Streptomyces
- Mechanisms of Antibody-based defense against Pneumocystis
- Characterization and Function of the Inflammatory Response to Infection by a Gastrointestinal Nematode Parasite: New Insights into Protective Th2 Responses
- Etude de l'implication des cellules iNKT dans l'asthme allergique expérimental
- Proteases from seafood as activators of protease-activated receptor-2 in airway epithelial cells
- Variation in airway remodelling genes and their role on asthma severity in children and young adults
- Secretion of the chitinolytic machinery in Serratia marcescens
- Creation of Customized Bioactivity within a 14-Membered Macrolide Scaffold: Design, Synthesis, and Biological Evaluation Using a Family-18 Chitinase.
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