In vivo half-life of a protein is a function of its amino-terminal residue.
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Summary
The recognition of an amino-terminal residue in a protein may mediate both the metabolic stability of the protein and the potential for regulation of its stability as predicted by the N-end rule.
- Type
- article
- Published
- 1986-10-10
- Cited by
- 1,891
- References
- 42
- OpenAlex
- https://openalex.org/W2071056869
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:44406264
Keywords
Amino acid, Biochemistry, Fusion protein, Saccharomyces cerevisiae, Ubiquitin
References
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- Yeast promoters and lacZ fusions designed to study expression of cloned genes in yeast.
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- Rapid intracellular turnover of adenovirus 5 early region 1A proteins
- hflB, a new Escherichia coli locus regulating lysogeny and the level of bacteriophage lambda cII protein.
- The ubiquitin system: functions and mechanisms
- Thermolability of ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85.
- Protein degradation in E. coli: The ion mutation and bacteriophage lambda N and cll protein stability
- Amino and carboxy-terminal regions in globular proteins.
- Multiple ubiquitin mRNAs during Xenopus laevis development contain tandem repeats of the 76 amino acid coding sequence.
- Analysis of gene control signals by DNA fusion and cloning in Escherichia coli.
- Ubiquitin dependence of selective protein degradation demonstrated in the mammalian cell cycle mutant ts85.
- Ubiquitin: roles in protein modification and breakdown.
- Protein modification by amino acid addition is increased in crushed sciatic but not optic nerves.
- Methionine or not methionine at the beginning of a protein
Cited by
- Natural substrates of the ubiquitin proteolytic pathway.
- Proper and improper folding of proteins in the cellular environment.
- Structure of preproattacin and its processing in insect cells infected with a recombinant baculovirus.
- N-Terminal Arginylation of Sciatic Nerve and Brain Proteins Following Injury
- The soluble but not mitochondrially bound hexokinase is a substrate for the ATP- and ubiquitin-dependent proteolytic system.
- A NOVEL CLASS OF IMMUNOPROTEASOME CATALYTIC SUBUNIT LMP2 INHIBITOR AND ITS THERAPEUTIC POTENTIALS IN CANCER
- Roles of ubiquitinylation in proteolysis and cellular regulation.
- Molecular analysis of the functional role of beta-adrenergic receptor kinase 1 amino-terminal.
- The catalytic sites of 20S proteasomes and their role in subunit maturation: a mutational and crystallographic study.
- Gene therapy and metabolic engineering.
- An Evaluation of Enforced Rapid Proteasomal Degradation as a Means of Enhancing Vaccine-Induced CTL Responses1
- Real-time analysis of apoptosis in vivo.
- Combined effect of protein fusion and signal sequence greatly enhances the production of recombinant human GM-CSF in Escherichia coli
- The ubiquitin-proteasome pathway and its role in cancer.
- Heat-inducible degron and the making of conditional mutants.
- Biochemical studies of the essential Clp protease in cyanobacteria and its associated adaptor proteins
- Early embryogenesis in pisum sativum L
- Implementing Arithmetic and Other Analytic Operations By Transcriptional Regulation
- The mysteries of nitrogen balance
- Enzymatic Blockade of the Ubiquitin-Proteasome Pathway
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