Tris (Hydroxymethyl) Aminomethane (THAM) Induced Stimulation of Insulin Release by Islets of Langerhans Previously Isolated from Rat Pancreas
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Summary
It is postulated that THAM molecules penetrate and act at intracellular loci to induce insulin release, possibly by chelating Zn complexed with insulin in beta cell granules.
- Type
- article
- Published
- 1970-08-01
- Cited by
- 9
- References
- 16
- OpenAlex
- https://openalex.org/W2070871775
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:30382909
Keywords
Tris, Hydroxymethyl, Insulin, Chemistry, Bicarbonate
References
- Submicroscopic histochemical demonstration of intracellular reactive zinc in beta cells of pancreatic islets.
- SOME IN VIVO AND IN VITRO OBSERVATIONS ON THE EFFECTS OF TRIS(HYDROXYMETHYL) AMINOMETHANE IN DIABETIC ACIDOSIS *
- Severe carbon dioxide intoxication. Treatment with organic buffer (trihvdroxymethvlaminomethane).
- TRIS BUFFER IN THE TREATMENT OF SEVERELY BURNED PATIENTS.
- Studies of a Simplified Plasma Insulin Immunoassay Using Cellulose Powder
- Method for the Isolation of Intact Islets of Langerhans from the Rat Pancreas
- Hypoglycemic Activity of Tris Buffer in Man and Dog
- Interaction Between Insulin and Zinc in the Islets of Langerhans
- The Stimulation of Insulin Secretion in Dogs by Tris (Hydroxymethyl) Aminomethane∗
- INTRACELLULAR HYDRION CONCENTRATION STUDIES: I. THE RELATION OF THE ENVIRONMENT TO THE PH OF PROTOPLASM AND OF ITS INCLUSION BODIES
- INTRACELLULAR HYDRION CONCENTRATION STUDIES
Cited by
- Disruption of the Golgi zone and inhibition of the conversion of proparathyroid hormone to parathyroid hormone in human parathyroid tissue by tris(hydroxymethyl)aminomethane.
- Insulin from individual isolated islets of Langerhans. 1: Response to glucose
- Inhibition of sucrase by tris in rat and man, demonstrated by oral loading tests with sucrose.
- Tris(hydroxymethyl)aminomethane Inhibits the Synthesis and Processing of Proinsulin in Isolated Rat Pancreatic Islets Without Affecting Release of Insulin Stores
- The Effects of Tri-Hydroxymethyl-Aminomethane (TRIS) on Plasma Levels of Insulin, Small Ions and Energetic Substrates in the Dog*
- The influence of sodium on calcium movements and catecholamine release in thin slices of bovine adrenal medulla.
- Pancreatic islet cells: electrogenic and electrodiffusional control of membrane potential.
- Electrical and Secretory Manifestations of Glucose and Amino Acid Interactions in Rat Pancreatic Islets
- Effect of open-heart surgery with hemodilution perfusion upon insulin secretion.
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