The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors.

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Summary

Investigation of the expression of human DNMT1, 3a and 3b found widespread, coordinate expression of all three transcripts in most normal tissues, and several novel alternatively spliced forms of DNMT3b, which may have altered enzymatic activity, were found to be expressed in a tissue-specific manner.

Type
article
Published
1999-01-01
Cited by
887
References
62
Access
Open access

Keywords

Biology, Methyltransferase, DNA methylation, DNMT3B, Methylation

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