The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors.
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Summary
Investigation of the expression of human DNMT1, 3a and 3b found widespread, coordinate expression of all three transcripts in most normal tissues, and several novel alternatively spliced forms of DNMT3b, which may have altered enzymatic activity, were found to be expressed in a tissue-specific manner.
- Type
- article
- Published
- 1999-01-01
- Cited by
- 887
- References
- 62
- Access
- Open access
- OpenAlex
- https://openalex.org/W2070484728
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:16791182
Keywords
Biology, Methyltransferase, DNA methylation, DNMT3B, Methylation
References
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- Epigenetic gene deregulation in cancer
- Beyond Watson and Crick: DNA Methylation and Molecular Enzymology of DNA Methyltransferases
- DNA Methyltransferase Deficiency Modifies Cancer Susceptibility in Mice Lacking DNA Mismatch Repair
- Overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, associated with DNA hypomethylation on pericentromeric satellite regions during human hepatocarcinogenesis
- Genomic imprinting and methylation: epigenetic canalization and conflict.
- HOXB13, a Target of DNMT3B, Is Methylated at an Upstream CpG Island, and Functions as a Tumor Suppressor in Primary Colorectal Tumors
- The role of epigenetic transcription repression and DNA methyltransferases in cancer
- Identification of abnormal gene expression in bovine transgenic somatic cell nuclear transfer embryos
- DNA methylation and cancer.
- Increased expression of hepatic DNA methyltransferase in smokers
- DNMT3b -149C/T promoter variants and methylation of colorectal cancer-associated genes
- Epigenetic transcriptional repression of tumor suppresor genes and its reversion by drugs.
- Apoptotic Signaling beyond Caspase Activation in Hepatocytes
- DNA methylation profiling of fish tumours
- Epigenetic-Based Therapies in Cancer
- Folate network genetic variation, plasma homocysteine, and global genomic methylation content: a genetic association study
- Cancer epigenetics: DNA methylation and chromatin alterations in human cancer.
- DNA methylation in chromatin - complexes and mechanisms
- Characterization of chromatin by use of high performance liquid chromatography tandem mass spectrometry for insights into the epigenetics of cancer
- Sustained epigenetic programming of POMC by early life stress
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