Tests for linkage and association in nuclear families.
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Summary
Two statistics are proposed that give valid chi2 tests of the null hypothesis of no association or no linkage and generally are more powerful than the TDT with a single, randomly chosen, affected child from each family.
- Type
- article
- Published
- 1997-08-01
- Cited by
- 216
- References
- 9
- Access
- Open access
- OpenAlex
- https://openalex.org/W2070134384
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:7202944
Keywords
Transmission disequilibrium test, Linkage disequilibrium, Linkage (software), Locus (genetics), Genetics
References
- Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM).
- An introduction to linear statistical models
- Evidence of linkage disequilibrium between schizophrenia and the SCa1 CAG repeat on chromosome 6p23.
- Power studies for the transmission/disequilibrium tests with multiple alleles.
- Linkage disequilibrium mapping of a type 1 diabetes susceptibility gene (IDDM7) to chromosome 2q31–q33
- The TDT and other family-based tests for linkage disequilibrium and association.
Cited by
- A Monte Carlo procedure for two‐stage tests with correlated data
- Family-based tests of association in the presence of linkage.
- Correcting for a potential bias in the pedigree disequilibrium test.
- Factors affecting statistical power in the detection of genetic association.
- Family-based designs in the age of large-scale gene-association studies
- Informative‐Transmission Disequilibrium Test (i‐TDT): combined linkage and association mapping that includes unaffected offspring as well as affected offspring
- A linkage study of autism using multipoint sib-pair analysis
- Statistical Methods for Identifying X-linked Genes Associated with Complex Phenotypes
- Analysis of Genetic Association Studies
- Linkage disequilibrium of a type 1 diabetes susceptibility locus with a regulatory IL12B allele
- Polymorphisms in Xenobiotic Metabolism Genes and Autism
- The role of interacting determinants in the localization of genes.
- Association tests using unaffected‐sibling versus pseudo‐sibling controls
- Association study designs for complex diseases
- Methodological Approaches to Study the Genetics of Dementia and Cognitive Function
- Significant evidence for linkage of a simulated trait to D1G024–A conclusion reached using multiallelic transmission/disequilibrium tests
- Evaluation of the contribution of environmental factors
- A point mutation in PTPRC is associated with the development of multiple sclerosis
- Two tests of association for a susceptibility locus for families of variable size: An example using two sampling strategies
- Genetics of T cell co-stimulatory receptors -CD28, CTLA4, ICOS and PDCD1 in immunity and transplantation
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