Targeted drug delivery to tumors: Myths, reality and possibility
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Summary
It would be profitable to address a variety of issues and factors that could affect the development of improved targeted drug delivery systems, including nanocarrier, nanovehicle, nanosystem, nanostructure, and other terms used in the literature.
- Type
- article
- Published
- 2011-06-06
- Cited by
- 1,777
- References
- 96
- Access
- Open access
- OpenAlex
- https://openalex.org/W2070003597
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:205870745
Keywords
Micelle, Doxorubicin, Chemistry, In vivo, Drug delivery
References
- Conjugation of poly(styrene-co-maleic acid) derivatives to the antitumor protein neocarzinostatin: pronounced improvements in pharmacological properties.
- Effect of liposome size on the circulation time and intraorgan distribution of amphipathic poly(ethylene glycol)-containing liposomes.
- Heterogeneity in cancer: cancer stem cells versus clonal evolution.
- Targeted therapies: a new generation of cancer treatments.
- Evaluation of the United States Food and Drug Administration-approved scoring and test system of HER-2 protein expression in breast cancer.
- A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.
- 50 years of preclinical anticancer drug screening: empirical to target-driven approaches.
- Relationship between antigen density and immunotherapeutic response elicited by monoclonal antibodies against solid tumors.
- Current constructs and targets in clinical development for antibody-based cancer therapy.
- Pegylation: a novel process for modifying pharmacokinetics.
- Delivering nanomedicine to solid tumors
- Intracellular fate of bioresponsive poly(amidoamine)s in vitro and in vivo.
- Hydrotropic polymeric micelles for enhanced paclitaxel solubility: in vitro and in vivo characterization.
- CPP-protein constructs induce a population of non-acidic vesicles during trafficking through endo-lysosomal pathway.
- New strategies for nucleic acid delivery to conquer cellular and nuclear membranes.
- The origins and evolution of "controlled" drug delivery systems.
- Development of copolymers of poly(d,l-lactide) and methoxypolyethylene glycol as micellar carriers of paclitaxel
- Folate-liposome-mediated antisense oligodeoxynucleotide targeting to cancer cells: evaluation in vitro and in vivo.
- The effects of particle size and molecular targeting on the intratumoral and subcellular distribution of polymeric nanoparticles.
- Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment.
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- Core–shell nanocarriers for cancer therapy. Part I: biologically oriented design rules
- Specific protein markers for stem cell cross-talk with neighboring cells in the environment.
- Accumulation, internalization and therapeutic efficacy of neuropilin-1-targeted liposomes
- Tumor-targeting dual peptides-modified cationic liposomes for delivery of siRNA and docetaxel to gliomas.
- Simulation of Complex Transport of Nanoparticles around a Tumor Using Tumor-Microenvironment-on-Chip
- iRGD-conjugated DSPE-PEG2000 nanomicelles for targeted delivery of salinomycin for treatment of both liver cancer cells and cancer stem cells.
- Antibody-targeted nanoparticles for cancer treatment.
- Macrophages as Active Nanocarriers for Targeted Early and Adjuvant Cancer Chemotherapy.
- Tumor stroma-containing 3D spheroid arrays: A tool to study nanoparticle penetration.
- Reversibly Switchable, pH-Dependent Peptide Ligand Binding via 3,5-Diiodotyrosine Substitutions.
- Designing polymer-tethered membrane-nanoparticle composites
- Stressing the Role of DNA as a Drug Carrier: Synthesis of DNA–Drug Conjugates through Grafting Chemotherapeutics onto Phosphorothioate Oligonucleotides
- Protein–Polymer Conjugates Synthesized Using Water-Soluble Azlactone-Functionalized Polymers Enable Receptor-Specific Cellular Uptake toward Targeted Drug Delivery
- DePEGylation strategies to increase cancer nanomedicine efficacy.
- Design, synthesis, and functionalization of nanomaterials for therapeutic drug delivery.
- NANOCRYSTALS OF CHEMOTHERAPEUTIC AGENTS FOR CANCER THERANOSTICS: DEVELOPMENT AND IN VITRO AND IN VIVO EVALUATION
- Nanomedicine: the promise and challenges in cancer chemotherapy.
- Glutamate-Leucine Block Copolypeptides for Drug Delivery
- Online open-tubular fractionation scheme coupled with push-pull perfusion sampling for profiling extravasation of gold nanoparticles in a mouse tumor model.
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