Promotion of microtubule assembly in vitro by taxol
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Summary
It is reported here that taxol acts as a promoter of calf brain microtubule assembly in vitro, in contrast to plant products such as colchicine and podophyllotoxin, which inhibit assembly.
- Type
- article
- Published
- 1979-02-01
- Cited by
- 3,520
- References
- 16
- OpenAlex
- https://openalex.org/W2067299834
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4315316
Keywords
Podophyllotoxin, Microtubule, Tubulin, HeLa, Colchicine
References
- Kinetic analysis of microtubule self-assembly in vitro.
- Molecules and cell movement
- Protein measurement with the Folin phenol reagent.
- A theory of linear and helical aggregations of macromolecules.
- Separation of apolipoproteins by an acrylamide-gradient sodium dodecyl sulfate gel electrophoresis system.
- A protein factor essential for microtubule assembly.
- Microtubule Formation in vitro in Solutions Containing Low Calcium Concentrations
- Head to tail polymerization of actin.
- The reconstitution of microtubules from purified calf brain tubulin.
- Turbidimetric studies of the in vitro assembly and disassembly of porcine neurotubules.
- Microtubule assembly in the absence of added nucleotides.
- Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia.
- Nucleotide binding and phosphorylation in microtubule assembly in vitro.
- A quantitative analysis of microtubule elongation
- Microtubules and intermediate filaments.
Cited by
- Taxol toxicity. Epithelial necrosis in the gastrointestinal tract associated with polymerized microtubule accumulation and mitotic arrest
- Therapeutic response to taxol of six human tumors xenografted into nude mice
- Metabolism of plant-derived anticancer agents.
- Preparation of neoclerodane diterpenes as probes for the opioid receptor system
- Expression of SLC transporters in Chronic Lymphocytic Leukaemia cells and their interaction with cytostatics
- Configurations of microtubules in artificially activated eggs of the sea urchin Lytechinus variegatus.
- Reformation of the marginal band of avian erythrocytes in vitro using calf-brain tubulin: peripheral determinants of microtubule form
- Effect of microtubule-associated proteins on the protofilament number of microtubules assembled in vitro.
- Redistribution of microtubules and Golgi apparatus in herpes simplex virus-infected cells and their role in viral exocytosis
- Taxol cytotoxicity on human leukemia cell lines is a function of their susceptibility to programmed cell death
- Microtubule inhibitors differentially affect translational movement, cell surface expression, and endocytosis of transferrin receptors in K562 cells
- Nerve growth factor prevents neurotoxic effects of cisplatin, vincristine and taxol, on adult rat sympathetic ganglion explants in vitro.
- Role of microtubules in contractile dysfunction of hypertrophied cardiocytes.
- Analysis of taxol and related diterpenoids from cell cultures by liquid chromatography-electrospray mass spectrometry.
- 3D QSAR studies for the beta-tubulin binding site of microtubule-stabilizing anticancer agents (MSAAs): a pseudoreceptor model for taxanes based on the experimental structure of tubulin.
- GS-164, a small synthetic compound, stimulates tubulin polymerization by a similar mechanism to that of Taxol
- Taxol-mediated changes in fibrosarcoma-induced immune cell function: Modulation of antitumor activities
- Phase I study of paclitaxel (taxol) and granulocyte colony stimulating factor (G-CSF) in patients with unresectable malignancy
- A steroid derivative with paclitaxel-like effects on tubulin polymerization.
- Structure-activity relationships study at the 3'-N position of paclitaxel. Part 2: synthesis and biological evaluation of 3'-N-thiourea- and 3'-N-thiocarbamate-bearing paclitaxel analogues.
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