Enhancement of Adeno-Associated Virus Infection by Mobilizing Capsids into and Out of the Nucleolus
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Summary
The hypothesis that rAAV2 virions enter the nucleus intact and can be sequestered in the nucleolus in stable form is supported, and cellular parameters that mobilize virions in the nucleus and significantly influence AAV infection are identified.
- Type
- article
- Published
- 2008-12-24
- Cited by
- 173
- References
- 79
- Access
- Open access
- OpenAlex
- https://openalex.org/W2066313345
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:8787031
Keywords
Nucleolin, Nucleolus, Biology, Nucleoplasm, Transduction (biophysics)
References
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- The Development of Human Gene Therapy
- Biology of adeno-associated virus.
- THE DEVELOPMENT OF HUMAN GENE THERAPY
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- Endosomal processing limits gene transfer to polarized airway epithelia by adeno-associated virus.
- Electron microscope study on the replication of AAV-1 in herpes-infected cells.
- Identification of nucleolin and nucleophosmin as genotoxic stress-responsive RNA-binding proteins.
- Observed Hysteresis of Virus Capsid Disassembly Is Implicit in Kinetic Models of Assembly*
- Electron microscopy of adenovirus-associated virus (AAV) in cell cultures.
- Intracellular trafficking of adeno-associated viral vectors
- Optimization of self-complementary AAV vectors for liver-directed expression results in sustained correction of hemophilia B at low vector dose.
- Controlled conformational transitions in the MVM virion expose the VP1 N-terminus and viral genome without particle disassembly.
- Infectious Entry Pathway of Adeno-Associated Virus and Adeno-Associated Virus Vectors
Cited by
- Exploiting high-throughput screens to optimize Adeno-Associated Viral Vectors for gene transfer into primary human keratinocytes
- Viral Single-Strand DNA Induces p53-Dependent Apoptosis in Human Embryonic Stem Cells
- Adeno-associated virus vectorology, manufacturing, and clinical applications.
- AAV capsid structure and cell interactions.
- Adeno-associated virus biology.
- Improving the immunogenicity of recombinant adeno-associated virus
- HIV-1 and the Nucleolus: A Role for Nucleophosmin/NPM1 in Viral Replication: A Dissertation
- Adeno-associated Virus as a Mammalian DNA Vector
- A journey to the center of the cell: Insights into subnuclear trafficking of the Rous sarcoma virus Gag polyprotein
- Adeno-associated viral vectors and their redirection to cell-type specific receptors.
- Nucleolin enhances the proliferation and migration of heat‐denatured human dermal fibroblasts
- AAV vectors for the nucleolus.
- AAV Exploits Subcellular Stress Associated with Inflammation, Endoplasmic Reticulum Expansion, and Misfolded Proteins in Models of Cystic Fibrosis
- AAV-Mediated Gene Targeting Is Significantly Enhanced by Transient Inhibition of Nonhomologous End Joining or the Proteasome In Vivo
- Impact of capsid modifications by selected peptide ligands on recombinant adeno-associated virus serotype 2-mediated gene transduction.
- Virus strategies for passing the nuclear envelope barrier
- Arsenic Trioxide Stabilizes Accumulations of Adeno-Associated Virus Virions at the Perinuclear Region, Increasing Transduction In Vitro and In Vivo
- Direct and Retrograde Transduction of Nigral Neurons with AAV6, 8, and 9 and Intraneuronal Persistence of Viral Particles
- Heparin-binding correlates with increased efficiency of AAV1- and AAV6-mediated transduction of striated muscle, but negatively impacts CNS transduction
- Promyelocytic Leukemia Protein Is a Cell-Intrinsic Factor Inhibiting Parvovirus DNA Replication
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