Using Multiplexed Assays of Oncogenic Drivers in Lung Cancers to Select Targeted Drugs
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Summary
The Lung Cancer Mutation Consortium was formed to perform multiplexed assays testing adenocarcinomas of the lung for drivers in 10 genes to enable clinicians to select targeted treatments and enroll patients into clinical trials.
- Type
- article
- Published
- 2014-05-21
- Cited by
- 1,645
- References
- 73
- OpenAlex
- https://openalex.org/W2065477010
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:205058899
Keywords
KRAS, Medicine, Lung cancer, Oncology, Genotyping
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- Angiogenesis inhibition as a therapeutic strategy in non-small cell lung cancer (NSCLC).
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- Surrogate clinical endpoints to predict overall survival in non-small cell lung cancer trials-are we in a new era?
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- Drinking Not Drowning: How to Deal With the Deluge of Potential Predictive Biomarker Approaches in Non-Small-Cell Lung Cancer.
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- Anti-tumor activity of osimertinib, an irreversible mutant-selective EGFR tyrosine kinase inhibitor, in NSCLC harboring EGFR Exon 20 Insertions
- Clinical outcomes of patients with resected, early-stage ALK-positive lung cancer
- Beyond SNPs—genetics, genomics and other ‘omic approaches to ARDS
- Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT): A Hybridization Capture-Based Next-Generation Sequencing Clinical Assay for Solid Tumor Molecular Oncology.
- Molekulardiagnostik des nichtkleinzelligen Lungenkarzinoms
- Targeting EGFR in lung cancer: Lessons learned and future perspectives
- Molecular Diagnostic Testing in Non-Small Cell Lung Cancer
- Refining the treatment of NSCLC according to histological and molecular subtypes
- miRNA-197 and miRNA-184 are associated with brain metastasis in EGFR-mutant lung cancers
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