A common signaling cascade may underlie "addiction" to the Src, BCR-ABL, and EGF receptor oncogenes.
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Summary
It is reported that differential attenuation rates of prosurvival and proapoptotic signals in oncogene-dependent cells contribute to cell death following oncogen inactivation, and it is suggested that "addiction" associated with apoptosis reflects an active rather than a passive process.
- Type
- article
- Published
- 2006-11-01
- Cited by
- 258
- References
- 38
- Access
- Open access
- OpenAlex
- https://openalex.org/W2065285374
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:7705592
Keywords
Oncogene, MAPK/ERK pathway, Biology, Proto-oncogene tyrosine-protein kinase Src, Cancer research
References
- Requirement for Ras/Rac1-Mediated p38 and c-Jun N-Terminal Kinase Signaling in Stat3 Transcriptional Activity Induced by the Src Oncoprotein
- Secondary mutation maintains the transformed state in BaF3 cells with inducible BCR/ABL expression.
- Janus faces of ras: anti or pro-apoptotic?
- Essential role for oncogenic Ras in tumour maintenance
- JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis
- Reversibility of acute B-cell leukaemia induced by BCR–ABL1
- STI571 as a Targeted Therapy for CML
- Disorders in cell circuitry associated with multistage carcinogenesis: exploitable targets for cancer prevention and therapy.
- Multiple responses to EGF receptor activation and their abrogation by a specific EGF receptor tyrosine kinase inhibitor
- Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis
- “Oncogenic Shock”: Explaining Oncogene Addiction through Differential Signal Attenuation
- Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress
- Regulation of both apoptosis and cell survival by the v-Src oncoprotein
- Reversible tumorigenesis by MYC in hematopoietic lineages.
- Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr–Abl positive cells
- Suppression of Ki‐ras p21 levels leading to growth inhibition of pancreatic cancer cell lines with Ki‐ras mutation but not those without Ki‐ras mutation
- Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways
- Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib.
- Role of PP2A in the regulation of p38 MAPK activation in bovine aortic endothelial cells exposed to cyclic strain
- Clustered CD20 induced apoptosis: src-family kinase, the proximal regulator of tyrosine phosphorylation, calcium influx, and caspase 3-dependent apoptosis.
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- Single cell cytometry of protein function in RNAi treated cells and in native populations
- Multidrug resistance in cancer.
- Targeting oncogenes with siRNAs.
- EXPLOITATION OF SMALL INTERFERING RNA METHODOLOGY TO IDENTIFY NOVEL ANTICANCER TREATMENTS
- Dualité fonctionnelle de LMP1 : implication dans l’apoptose et la transformation cellulaire
- Pre-B cell receptor signaling prevents malignant transformation by BCR-ABL1
- Myc oncoprotein-cofactor interactions : Function, regulation and targeting
- Dormancy of metastatic melanoma
- Novel interactions of GRP78: UPR and estrogen responses in the brain
- BIM MEDIATES IMATINIB-INDUCED APOPTOSIS OF GASTROINTESTINAL STROMAL TUMORS: TRANSLATIONAL IMPLICATIONS
- Development Of A Vaccine Targeting Triple-Negative Breast Cancer
- NCI's provocative questions on cancer: some answers to ignite discussion
- Regulation of EGF receptor dynamics by protein tyrosine phosphatases
- Unveiling the Molecular Mechanisms Regulating the Activation of the ErbB Family Receptors at Atomic Resolution through Molecular Modeling and Simulations
- DEFINING THE ROLE OF EGFR ACETYLATION IN CELLULAR PROCESSES: CLINICAL IMPLICATIONS
- Anoikis of colon carcinoma cells triggered by β-catenin loss can be enhanced by tumor necrosis factor receptor 1 antagonists
- Epidermal growth factor receptor mutations in lung cancer
- Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer
- Gefitinib-Resistance Is Related to BIM Expression in Non-Small Cell Lung Cancer Cell Lines
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