Buffer Combinations for Mammalian Cell Culture

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Summary

The growth and metabolism of cultured mammalian cells are markedly affected by the pH variation in ordinary hicarbonate-buffered media, but those pH swings can be reduced and the pH of the culture can be stabilized as desired in the range pH 6.4 to 8.3 by appropriate combinations of two or three organic buffers.

Type
article
Published
1971-10-29
Cited by
263
References
16

Keywords

Bicarbonate, Phosphate buffered saline, Metabolism, Cell culture, Chemistry

References

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