Endotoxin hepatotoxicity augmented by ethanol.
Explore this paper's citation graph
Summary
It is suggested that acute administration of alcohol enhances endotoxin hepatotoxicity when the dose of endotoxin is small, but that the effect of alcohol is masked when larger doses of endot toxin are given.
- Type
- article
- Published
- 1991-10-01
- Cited by
- 52
- References
- 24
- OpenAlex
- https://openalex.org/W2063486877
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:44977177
Keywords
Ethanol, Alcohol, Chemistry, Body weight, Toxicity
References
- Endotoxemia in patients with alcoholic and non-alcoholic cirrhosis and in subjects with no evidence of chronic liver disease following acute alcohol excess.
- Interaction of ethanol with drugs, hepatotoxic agents, carcinogens and vitamins.
- Lipid peroxidation and cellular damage in toxic liver injury.
- The role of lipid peroxidation in endotoxin-induced hepatic damage and the protective effect of antioxidants.
- Oxygen-derived free radicals promote hepatic injury in the rat.
- Endotoxin induced hepatic necrosis in rats on an alcohol diet
- The leaky gut of alcoholism: possible route of entry for toxic compounds.
- Endotoxin‐induced hypercoagulability: A possible aggravating factor of alcoholic liver disease
- Reticuloendothelial function in patients with alcoholic liver cirrhosis.
- Role of reactive oxygen intermediates in the hepatotoxicity of endotoxin.
- Mechanism of ethanol induced hepatic injury.
- Enhanced hepatotoxicity of endotoxin by hypoxia.
- Progress in Liver Disease
- Experimental alcohol-induced hepatic necrosis: suppression by propylthiouracil.
- Relation of the reticuloendothelial function to endotoxin hepatotoxicity.
- Endotoxin, reticuloendothelial function, and liver injury
- Clearance capacity of rat liver Kupffer, Endothelial, and parenchymal cells.
- Peroxidation of Liver Lipids in the Pathogenesis of the Ethanol-Induced Fatty Liver
- The adaptive increase in ethanol metabolism due to pretreatment with ethanol: a rapid phenomenon.
- Alcohol induced depression of reticuloendothelial function in the rat.
Cited by
- Modulation of the NO/cGMP pathway reduces the vasoconstriction induced by acellular and PEGylated haemoglobin.
- Metabolism of ethanol and some associated adverse effects on the liver and the stomach.
- Severity of liver injury in experimental alcoholic liver disease. Correlation with plasma endotoxin, prostaglandin E2, leukotriene B4, and thromboxane B2.
- Alcohol and the liver: 1994 update.
- Microbial metabolism of ethanol and acetaldehyde and clinical consequences
- Lactobacillus Feeding Reduces Endotoxemia and Severity of Experimental Alcoholic Liver (Disease)
- Gentle organ manipulation during harvest as a key determinant of survival of fatty livers after transplantation in the rat
- Mechanisms of ethanol-drug-nutrition interactions.
- Influence of a thiazole derivative on ethanol and thermally oxidized sunflower oil‐induced oxidative stress
- Burn injury sensitizes rat Kupffer cells via mechanisms dependent on gut-derived endotoxin
- Intestinal Barrier Function: Molecular Regulation and Disease Pathogenesis
- Aetiology and pathogenesis of alcoholic liver disease.
- Alcohol causes both tolerance and sensitization of rat Kupffer cells via mechanisms dependent on endotoxin.
- Towards a novel haemoglobin-based oxygen carrier: Euro-PEG-Hb, physico-chemical properties, vasoactivity and renal filtration.
- Detection of lipopolysaccharide in hemoglobin-vesicles by Limulus amebocyte lysate test with kinetic-turbidimetric gel clotting analysis and pretreatment of surfactant.
- Ethanol Impairs Intestinal Barrier Function in Humans through Mitogen Activated Protein Kinase Signaling: A Combined In Vivo and In Vitro Approach
- Role of Cuminum cyminum on Ethanol and Preheated Sunflower Oil Induced Lipid Peroxidation
- Role of Kupffer cells and gut‐derived endotoxins in alcoholic liver injury1
- Leaky gut in alcoholic cirrhosis: a possible mechanism for alcohol-induced liver damage
- The phosphodiesterase III inhibitor olprinone decreases sensitivity of rat Kupffer cells to endotoxin.
Related papers
- Ethanol consumption by rats is inversely related to hepatic alcohol dehydrogenase activity
- Cyclic expression of class I alcohol dehydrogenase in male rats treated with ethanol.
- Isotopic probes into pathways of ethanol metabolism.
- Increased alcohol dehydrogenase independent ethanol oxidation at high ethanol concentrations in isolated rat hepatocytes: the effect of chronic ethanol feeding.
- In vivo inhibition of liver alcohol dehydrogenase by ethanol administration.
- Ethanol metabolism in perfused rat liver at low ethanol concentrations: involvement of alcohol dehydrogenase in the adaptive increase in ethanol metabolism due to chronic pretreatment with ethanol.
- Behavioral and enzymatic interactions between benzyl alcohol and ethanol.
- Effects of ethyleneglycol dinitrate and related compounds on ethanol preference and ethanol metabolism.
- Metabolism of ethanol and fructose in the perfused rat liver.