In search of partners: linking extracellular proteases to substrates
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Summary
Proteases function as molecular switches in signalling circuits at the cell surface and in the extracellular milieu and elucidating the substrate degradomes of proteases will help to understand the function of protease in development and disease and to validate proteases as drug targets.
- Type
- review
- Published
- 2007-03-01
- Cited by
- 360
- References
- 128
- OpenAlex
- https://openalex.org/W2061945526
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:21438832
Keywords
Proteases, Cleave, Extracellular, Cell biology, Function (biology)
References
- Inhibitory antibodies against endopeptidase activity of human adamalysin 19.
- Protease degradomics: A new challenge for proteomics
- Identification of a peptide released during autocatalytic activation of trypsinogen.
- Determination of protease cleavage site motifs using mixture-based oriented peptide libraries
- The role of prohormone convertase‐2 in hypothalamic neuropeptide processing: a quantitative neuropeptidomic study
- X‐ray Structures of Human Neutrophil Collagenase Complexed with Peptide Hydroxamate and Peptide Thiol Inhibitors
- Biochemical properties and functions of membrane-anchored metalloprotease-disintegrin proteins (ADAMs).
- Rapid optimization of enzyme substrates using defined substrate mixtures.
- Large-scale analysis of the yeast proteome by multidimensional protein identification technology
- Role of TIMPs (tissue inhibitors of metalloproteinases) in pericellular proteolysis: the specificity is in the detail.
- An Enzyme Cascade in the Blood Clotting Mechanism, and its Function as a Biochemical Amplifier
- Dilating the degradome: matrix metalloproteinase 2 (MMP-2) cuts to the heart of the matter.
- Intramembrane proteolysis by presenilin and presenilin-like proteases
- Substrate phage: selection of protease substrates by monovalent phage display.
- Cooperation between Mast Cell Carboxypeptidase A and the Chymase Mouse Mast Cell Protease 4 in the Formation and Degradation of Angiotensin II*
- Regulation of Human ADAM 12 Protease by the Prodomain
- Control of Peripheral Nerve Myelination by the ß-Secretase BACE1
- Membrane-bound TNF supports secondary lymphoid organ structure but is subservient to secreted TNF in driving autoimmune inflammation.
- The Lin12-Notch Repeats of Pregnancy-associated Plasma Protein-A Bind Calcium and Determine Its Proteolytic Specificity*
- Differential dimethyl labeling of N-termini of peptides after guanidination for proteome analysis.
Cited by
- The blood–brain and the blood–cerebrospinal fluid barriers: function and dysfunction
- The pancreatic beta cell surface proteome
- A Highly Scalable Peptide-Based Assay System for Proteomics
- Coiled Coils Ensure the Physiological Ectodomain Shedding of Collagen XVII*
- Picking up the pieces: a generic porous Si biosensor for probing the proteolytic products of enzymes.
- A proteomic approach for the elucidation of the specificity of ectodomain shedding.
- Performing comparative peptidomics analyses of Salmonella from different growth conditions.
- Finding the needles in the haystack: mapping constitutive proteolytic events in vivo.
- Membrane protease degradomics: proteomic identification and quantification of cell surface protease substrates.
- Differential Regulation of Two- and Three-Dimensional Cell Function.
- Screening for Cold-Active Protease-Producing Bacteria from the Culture Collection of Polar Microorganisms and Characterization of Proteolytic Activities
- The chymase mouse mast cell protease 4 degrades TNF, limits inflammation, and promotes survival in a model of sepsis.
- Proteolytic profiling with imaging agents for rational design of target-activated peptide prodrugs
- ADAMTS1 i TFPI-2: Estudi de la seva interacció funcional i les implicacions en la plasticitat tumoral.
- Proteomic Profiling of Pro and Active Matrix Metalloproteinases using Tandem Mass Spectrometry. Optimization of Affinity Chromatography and nHPLC-MALDI-MS/MS for Proteomic discrimination of Matrix Metalloproteinases in pre-clinical Cancer Model.
- Characterising the interaction between metastasis-associated protein S100A4 and non-muscle myosin IIA in vitro and in vivo
- The Role of ADAM10 in the Immune System: Maintenance of Lymphoid Architecture,MDSC Development and Function, B cell Derived Exosomal Antigen Presentation, andB1 cell IgE Production.
- The role of Fyn and B-cell expressed ADAM10 in early B cell development, germinal center formation and terminal B cell differentiation
- Ectodomain Shedding Generates Neoepitopes on Collagen XVII, the Major Autoantigen for Bullous Pemphigoid
- Fell‐Muir Lecture: Metalloproteinases: from demolition squad to master regulators
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