Dorsal column sensory axons degenerate due to impaired microvascular perfusion after spinal cord injury in rats
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Summary
Data suggest that focal spinal cord ischemia causes both oligodendrocyte and axon degeneration, which are perhaps linked, and highlight the need of limiting the penumbral spread of ischemia and oligodendrocyte loss after SCI in order to protect axons.
- Type
- article
- Published
- 2013-08-23
- Cited by
- 21
- References
- 55
- Access
- Open access
- OpenAlex
- https://openalex.org/W2059715493
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24299828
Keywords
Axon, Spinal cord, Oligodendrocyte, Anatomy, White matter
References
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- Neurotrophic factors attenuate microvascular permeability disturbances and axonal injury following trauma to the rat spinal cord.
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- Sustained induction of heme oxygenase-1 in the traumatized spinal cord.
- Chronic alterations in the cellular composition of spinal cord white matter following contusion injury
- CD47 Knockout Mice Exhibit Improved Recovery from Spinal Cord Injury
- Microangiographic observations of the experimentally traumatized spinal cord.
- Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection.
- Unilateral dorsal column and rubrospinal tract injuries affect overground locomotion in the unrestrained rat
- Characterization of photochemically induced spinal cord injury in the rat by light and electron microscopy.
- Anoxic and Ischemic Injury of Myelinated Axons in CNS White Matter: From Mechanistic Concepts to Therapeutics
- Intravenous Infusion of Magnesium Chloride Improves Epicenter Blood Flow during the Acute Stage of Contusive Spinal Cord Injury in Rats
- Rescuing vasculature with intravenous angiopoietin-1 and alpha v beta 3 integrin peptide is protective after spinal cord injury.
- The relationships among the severity of spinal cord injury, residual neurological function, axon counts, and counts of retrogradely labeled neurons after experimental spinal cord injury.
- Regional spinal cord blood flow in rats after severe cord trauma.
- In vivo imaging of single axons in the mouse spinal cord
- Improvement in post-traumatic spinal cord blood flow with a combination of a calcium channel blocker and a vasopressor.
- Targeting Microvasculature for Neuroprotection after SCI
Cited by
- Recent Advances in the Pharmacologic Treatment of Spinal Cord Injury
- Beneficial effects of thymosin β4 on spinal cord injury in the rat.
- Intrathecal Acetyl-l-Carnitine Protects Tissue and Improves Function after a Mild Contusive Spinal Cord Injury in Rats
- Does being female provide a neuroprotective advantage following spinal cord injury?
- Melatonin prevents blood vessel loss and neurological impairment induced by spinal cord injury in rats
- Ethyl pyruvate modulates delayed paralysis following thoracic aortic ischemia reperfusion in mice.
- Reduced FAK-STAT3 signaling contributes to ER stress-induced mitochondrial dysfunction and death in endothelial cells
- The Biology of Regeneration Failure and Success After Spinal Cord Injury.
- Axonal degeneration and demyelination following traumatic spinal cord injury: A systematic review and meta-analysis.
- Retracted Article: Melatonin protects spinal cord injury by up-regulating IGFBP3 through the improvement of microcirculation in a rat model
- Microtubule Stabilization Promotes Microcirculation Reconstruction After Spinal Cord Injury
- M2 Macrophages Promote PDGFRβ+ Pericytes Migration After Spinal Cord Injury in Mice via PDGFB/PDGFRβ Pathway
- Clemastine Enhances Myelination, Delays Axonal Loss and Promotes Functional Recovery in Spinal Cord Injury
- Mitochondrial function in spinal cord injury and regeneration
- Effects of fluids vs. vasopressors on spinal cord microperfusion in hemorrhagic shock induced ischemia/reperfusion.
- Surgical Decompression of Traumatic Cervical Spinal Cord Injury: A Pilot Study Comparing Real-Time Intraoperative Ultrasound After Laminectomy With Postoperative MRI and CT Myelography
- Neuron-Derived Exosomes Promote the Recovery of Spinal Cord Injury by Modulating Nerve Cells in the Cellular Microenvironment of the Lesion Area
- Trigeminal nerve stimulation: a current state-of-the-art review
- Emerging trends in the blood spinal-cord barrier: A bibliometric analysis
- Applications of Stem Cell-Derived Extracellular Vesicles in Nerve Regeneration
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