Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine
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Summary
The cloning of a gene that encodes a dopamine receptor gene that has high homology to the human dopamine D2 and D3 receptor genes is reported, which suggests the existence of other types of dopamine receptors which are more sensitive to clozapine.
- Type
- article
- Published
- 1991-04-18
- Cited by
- 2,018
- References
- 26
- Access
- Open access
- OpenAlex
- https://openalex.org/W2059230444
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4244670
Keywords
Clozapine, Dopamine receptor D2, Dopamine receptor D3, Dopamine receptor, Receptor
References
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- Cloning and expression of murine immune interferon cDNA.
- Atypical neuroleptics: role of multiple receptors, endogenous dopamine, and receptor linkage
- Alternative splicing directs the expression of two D2 dopamine receptor isoforms
- [125]I-spectramide: a novel benzamide displaying potent and selective effects at the D2 dopamine receptor.
- Removal of phosphorylation sites from the β2-adrenergic receptor delays onset of agonist-promoted desensitization
- Cloning and expression of human and rat Dt dopamine receptors
- Splicing and the formation of stable RNA.
- Human brain D1 and D2 dopamine receptors in schizophrenia, Alzheimer's, Parkinson's, and Huntington's diseases.
Cited by
- Transient decrease in rat striatal D2 dopamine receptor mRNA level after acute haloperidol treatment.
- Synthesis and characterization of biotinylated and photoactivatable neuroleptics. Novel bifunctional probes for dopamine receptors.
- Localization of the D5 dopamine receptor gene to human chromosome 4p15.1-p15.3, centromeric to the Huntington's disease locus.
- Dopamine D4 receptor deficiency alters behavioral responsiveness of mice to methylphenidate
- Heterómeros de receptores de dopamina. Nuevos mecanismos para la regulación de la transmisión dopaminérgica
- DRD4 dopamine receptor genotype and CSF monoamine metabolites in Finnish alcoholics and controls.
- Absence of detectable striatal dopamine D4 receptors in drug-treated schizophrenia.
- Dopamine and sexual behavior.
- Localisation of dopamine D2-like receptors in pulmonary artery of the human and rabbit but not of the rat.
- Etiopathogenesis and treatment of psychosis.
- Distribution of a novel mutation in the first exon of the human dopamine D4 receptor gene in psychotic patients.
- Molecular cloning, stable expression and desensitization of the human dopamine D1b/D5 receptor.
- Characterization of the Genomic Structure, Promoter Region, and a Tetranucleotide Repeat Polymorphism of the Human Neurotensin Receptor Gene*
- Muscarinic m4 receptor activation by some atypical antipsychotic drugs.
- Inhibition of synaptic transmission and epileptiform activity in central neurones by fluspirilene
- No association between polymorphisms in the human dopamine D3 and D4 receptors genes and alcoholism.
- Should Clozapine Be a First‐line Treatment for Schizophrenia? The Rationale for a Double‐Blind Clinical Trial in First‐Episode Patients
- Amisulpride versus flupentixol in schizophrenia with predominantly positive symptomatology – a double-blind controlled study comparing a selective D2-like antagonist to a mixed D1-/D2-like antagonist
- Differential regional and cellular distribution of dopamine D2‐like receptors: An immunocytochemical study of subtype‐specific antibodies in rat and human brain
- Anatomy and function of dopamine receptors: understanding the pathophysiology of fluctuations in Parkinson's disease.
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