Copper toxicity, oxidative stress, and antioxidant nutrients.
Explore this paper's citation graph
Summary
Results obtained from available animal studies suggest that the compound is protective, and further studies are needed to better understand the cellular effects of this essential, but potentially toxic, trace mineral and its functional interaction with other nutrients.
- Type
- review
- Published
- 2003-07-15
- Cited by
- 1,985
- References
- 144
- OpenAlex
- https://openalex.org/W2059073584
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:32142153
Keywords
Oxidative stress, Ascorbic acid, Antioxidant, Chemistry, Toxicity
References
- Aspirin reduces blood cholesterol in copper-deficient rats: a potential antioxidant agent?
- Acute copper poisoning. An outbreak traced to contaminated water from a corroded geyser.
- Oxidant injury to hepatic mitochondrial lipids in rats with dietary copper overload. Modification by vitamin E deficiency.
- Copper absorption as affected by supplemental calcium, magnesium, manganese, selenium and potassium.
- Autoradiographic analysis of gonadotropin binding to rat ovarian tissue sections.
- Effects of copper overload on hepatic lipid peroxidation and antioxidant defense in rats.
- Copper nutriture, bioavailability, and the influence of dietary factors.
- Influence of dietary rapeseed oil, vitamin E, and copper on the performance and the antioxidative and oxidative status of pigs.
- Gastrointestinal upsets and new copper plumbing--is there a connection?
- The failure of selenium supplementation to prevent copper-induced liver damage in Fischer 344 rats.
- Host defenses against copper toxicity.
- Autoxidation of amyloid precursor protein and formation of reactive oxygen species.
- Effect of excess dietary copper, iron or zinc on the tocopherol and selenium status of growing pigs.
- Effect of varying ascorbic acid intakes on copper absorption and ceruloplasmin levels of young men.
- Decreased brain ascorbate levels in copper-deficient mice and in brindled mice.
- Modern Nutrition in Health and Disease
- Interrelationship of dietary ascorbic acid and iron on the tissue distribution of ascorbic acid, iron and copper in female guinea pigs.
- Stimulation of lipid peroxidation and hydroxyl-radical generation by the contents of human atherosclerotic lesions.
- Covalent modification of guanine bases in double-stranded DNA. The 1.2-A Z-DNA structure of d(CGCGCG) in the presence of CuCl2.
- A postabsorption effect of L-ascorbic acid on copper metabolism in chicks.
Cited by
- Impact of selenium, iron, copper and zinc in on/off Parkinson's patients on L-dopa therapy.
- Copper induces cellular senescence in human glioblastoma multiforme cells through downregulation of Bmi-1.
- Profiling transcriptomic response of Enchytraeus albidus to Cu and Ni: comparison with Cd and Zn.
- Bacterial multi-drug efflux transporters
- The effects of point pollutants-originated heavy metals (lead, copper, iron, and cadmium) on fish living in Yeşilırmak River, Turkey
- A Cu-free clickable fluorescent probe for intracellular targeting of small biomolecules.
- Evaluation of the Interactions between Water Extractable Soil Organic Matter and Metal Cations (Cu(II), Eu(III)) Using Excitation-Emission Matrix Combined with Parallel Factor Analysis
- Cooperative capture synthesis: yet another playground for copper-free click chemistry.
- Copper-induced metabolic variation of oysters overwhelmed by salinity effects.
- Glutathione-Mediated Cu(I)/Cu(II) Complexes: Valence-Dependent Effects on Clearance and In Vivo Imaging Application
- Biochemical CuSO4 Toxicity in Drosophila melanogaster Depends on Sex and Developmental Stage of Exposure
- Trace metal limitation and its role in oxidative stress of coral algal symbionts; implications for thermally induced coral bleaching events.
- New sphingolipid probes for metabolism and trafficking studies
- Controlling Surface Chemistry on the Microscopic and Nanoscopic Scale through Photopatterned Self-Assembled Monolayers
- Apoptosis in cancer and atherosclerosis: polyphenol activities.
- Expression and cellular localization of Copper transporter 2 (Ctr2) in Mus musculus
- Comparative genomics analysis of the metallomes.
- Influence of Selective Conditions on Various Composite Sorbents for Enhanced Removal of Copper (II) Ions from Aqueous Environments
- Exposure of workers to nickel, copper and lead in a base metal recovery plant and laboratory
- Subclinical diastolic dysfunction in children with Wilson’s disease assessed by tissue Doppler echocardiography: a possible early predictor of cardiac involvement
Related papers
- Changes in the ascorbic acid content of the white blood as an index of the vitamin C condition of the body
- Connective tissue studies. IV. L-ascorbic-I-C14 acid excretion in intact and wounded guinea pigs on varying vitamin C intakes.
- Vitamin C and Ascorbic Acid
- Determination of the ascorbic acid content of two medicinal plants in Nigeria.
- Hormetic dose response to L-ascorbic acid as an anti-cancer drug in colorectal cancer cell lines according to SVCT-2 expression
- Ascorbic Acid as Modulator of Immune Function in Sepsis