CHALLENGES IN PHENOTYPE DEFINITION IN THE WHOLE-GENOME ERA: MULTIVARIATE MODELS OF MEMORY AND INTELLIGENCE
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Summary
This work provides a framework for defining and refining latent constructs used in neuroscience research and then applies this strategy to review known genetic contributions to memory and intelligence in healthy individuals to build multi-level phenotype models that express the interactions between constructs necessary to understand complex neuropsychiatric diseases.
- Type
- review
- Published
- 2009-05-18
- Cited by
- 67
- References
- 129
- Access
- Open access
- OpenAlex
- https://openalex.org/W2057328389
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:39617129
Keywords
Phenomics, Schizophrenia (object-oriented programming), Autism, Psychology, Neuroscience
References
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Cited by
- Towards an Ontology of Cognitive Control
- Behavioral toxicology in the 21st century: challenges and opportunities for behavioral scientists. Summary of a symposium presented at the annual meeting of the neurobehavioral teratology society, June, 2009.
- Genome-Wide Association Mapping for Intelligence in Military Working Dogs: Canine Cohort, Canine Intelligence Assessment Regimen, Genome-Wide Single Nucleotide Polymorphism (SNP) Typing, and Unsupervised Classification Algorithm for Genome-Wide Association Data Analysis
- Étude des anomalies du développement humain# un modèle d’analyse phénotypique
- Dissecting genetic interactions in complex traits
- Neurobiological heterogeneity in ADHD
- Searching for susceptibility genes for psychosis in late-onset Alzheimer's disease
- Empirically Derived Subtypes of Opioid Use and Related Behaviors
- Improved Methods to Identify Stable, Highly Heritable Subtypes of Opioid Use and Related Behaviors
- Graphical data mining of human cortical surface morphometry
- Meta-analysis methods for genome-wide association studies and beyond
- Fine-mapping of the brain-derived neurotrophic factor (BDNF) gene supports an association of the Val66Met polymorphism with episodic memory.
- Moving Ahead with the Schizophrenia Concept: From the Elephant to the Mouse
- Phenomics: The systematic study of phenotypes on a genome-wide scale
- High-throughput cognitive assessment using BrainTest.org: examining cognitive control in a family cohort
- The Search for Biomarkers and Endophenotypes in Functional Gastrointestinal Disorders
- Phenotype refinement for comorbid attention deficit hyperactivity disorder and reading disability
- Behavioral toxicology in the 21st century: Challenges and opportunities for behavioral scientists
- COMT influences on prefrontal and striatal b responses during working memory among individuals with schizophrenia, their siblings and healthy controls
- The Genetics of Cognitive Impairment in Schizophrenia: A Phenomic Perspective
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