Calcineurin-mediated LTD of GABAergic inhibition underlies the increased excitability of CA1 neurons associated with LTP.
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Summary
The tetanus that elicits NMDA-dependent LTP mediates a coordinately regulated double function that produces LTP of the EPSP and, concomitantly, LTD of the IPSP that leads to enhancement of E-S coupling.
- Type
- article
- Published
- 2000-04-01
- Cited by
- 305
- References
- 42
- Access
- Open access
- OpenAlex
- https://openalex.org/W2056722870
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:17820120
Keywords
Long-term potentiation, Neuroscience, Calcineurin, GABAergic, Chemistry
References
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- Localization of sodium channels in cultured neural cells
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- Contrasting properties of two forms of long-term potentiation in the hippocampus
- Field potential evidence for long-term potentiation of feed-forward inhibition in the rat dentate gyrus.
- Postsynaptic calcium is sufficient for potentiation of hippocampal synaptic transmission.
- Spontaneous inhibitory post-synaptic potentials in hippocampus: mechanism for tonic inhibition.
- Heterosynaptic changes accompany long‐term but not short‐term potentiation of the perforant path in the anaesthetized rat.
- Inhibitors of protein kinases and phosphatases.
- Synaptically triggered action potentials begin as a depolarizing ramp in rat hippocampal neurones in vitro.
- Fast pre-potential generation in rat hippocampal CA1 pyramidal neurons.
- Long‐lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path
- Activation of NMDA receptors blocks GABAergic inhibition in an in vitro model of epilepsy
Cited by
- The effect of calcineurin activator, extracted from Chinese herbal medicine, on memory and immunity in mice.
- The other side of the engram: experience-driven changes in neuronal intrinsic excitability
- Regulation of GABAARs by Phosphorylation
- Neuromodulation des réseaux neuronaux : contrôle sérotoninergique de la balance excitation-inhibition dans le cortex visuel de rat.
- Plasticity of Local-Circuit Constraint Properties During Functional Reorganization of Adult Cortex
- Plasticité intrathalamique des synapses inhibitrices : implication des canaux calciques de type T dans la LTD des synapses NRT-TC lors des rythmes du sommeil profond.
- Differential Alterations in Excitatory and Inhibitory Networks Involving Dentate Granule Cells Following Chronic Treatment with Distinct Classes of NMDAR Antagonists in Hippocampal Slice Cultures
- Forms and Mechanisms of Homeostatic Synaptic Plasticity
- Approche environnementale et génétique de la sensibilité comportementale et moléculaire à deux psychotropes : la cocaïne et la fluoxétine
- Status Epilepticus Results in a Duration-Dependent Increased Protein Kinase A Activity in the Rat Pilocarpine Model
- A Cellular Mechanism for Dendritic Spine Loss Following Traumautic Brain Injury in Rat
- Neuroprzekaźnik hamujący w plastyczności kory mózgu
- Intracellular chloride and hydrogen ion dynamics in the nervous system
- Pathological Upregulation of a Calcium-Stimulated Phosphatase, Calcineurin, in Two Models of Neuronal Injury
- Diverse impact of neuronal activity at θ frequency on hippocampal long‐term plasticity
- Disruption of Slc4a10 augments neuronal excitability and modulates synaptic short-term plasticity
- Enhancement of presynaptic neuronal excitability by correlated presynaptic and postsynaptic spiking
- Hydrogen Peroxide Modulation of Synaptic Plasticity
- A significant increase in both basal and maximal calcineurin activity in the rat pilocarpine model of status epilepticus
- LTP of GABAergic synapses in the ventral tegmental area and beyond
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