Icariin inhibits osteoclast differentiation and bone resorption by suppression of MAPKs/NF-κB regulated HIF-1α and PGE(2) synthesis.
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Summary
It is demonstrated that icariin has an in vitro inhibitory effects on osteoclasts differentiation that can prevent inflammatory bone loss.
- Type
- article
- Published
- 2011-01-15
- Cited by
- 186
- References
- 48
- OpenAlex
- https://openalex.org/W2056427474
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24642094
Keywords
Osteoclast, Icariin, Bone resorption, Chemistry, Resorption
References
- Inhibition of osteoclast differentiation by polycyclic aryl hydrocarbons is dependent on cell density and RANKL concentration.
- The role of cyclooxygenase-2 (COX-2) in inflammatory bone resorption.
- Icariin inhibits the osteoclast formation induced by RANKL and macrophage-colony stimulating factor in mouse bone marrow culture.
- Lipopolysaccharide Promotes the Survival of Osteoclasts Via Toll-Like Receptor 4, but Cytokine Production of Osteoclasts in Response to Lipopolysaccharide Is Different from That of Macrophages 1
- Icaritin and its glycosides enhance osteoblastic, but suppress osteoclastic, differentiation and activity in vitro.
- Bone resorption by osteoclasts.
- Osteoimmunology: interactions of the bone and immune system.
- Acute hypoxia and osteoclast activity: a balance between enhanced resorption and increased apoptosis
- A p38 mitogen-activated protein kinase inhibitor arrests active alveolar bone loss in a rat periodontitis model.
- Bisphosphonate treatment of osteoporosis.
- The catabolic pathway mediated by Toll-like receptors in human osteoarthritic chondrocytes.
- LPS Induces Hypoxia-Inducible Factor 1 Activation in Macrophage-Differentiated Cells in a Reactive Oxygen Species–Dependent Manner
- Fc receptor gamma-chain activation via hOSCAR induces survival and maturation of dendritic cells and modulates Toll-like receptor responses.
- Epimedium‐Derived Phytoestrogen Flavonoids Exert Beneficial Effect on Preventing Bone Loss in Late Postmenopausal Women: A 24‐Month Randomized, Double‐Blind and Placebo‐Controlled Trial
- Therapeutic approaches to bone diseases.
- Osteoclast size is controlled by Fra-2 through LIF/LIF-receptor signalling and hypoxia
- Surface RANKL of Toll-like receptor 4-stimulated human neutrophils activates osteoclastic bone resorption.
- Icariin induces osteogenic differentiation in vitro in a BMP- and Runx2-dependent manner.
- Osteoimmunology--the hidden immune regulation of bone.
- Molecular Mechanism of the Bifunctional Role of Lipopolysaccharide in Osteoclastogenesis*
Cited by
- Icariin potentiates the antitumor activity of gemcitabine in gallbladder cancer by suppressing NF-κB
- Gambogic acid inhibits osteoclast formation and ovariectomy-induced osteoporosis by suppressing the JNK, p38 and Akt signalling pathways.
- Repair of Critical Calvarias Defects With Systemic Epimedium sagittatum Extract
- The effect of icariin on bone metabolism and its potential clinical application
- Icariin prevents cytokine-induced β-cell death by inhibiting NF-κB signaling.
- Icariin protects against titanium particle-induced osteolysis and inflammatory response in a mouse calvarial model.
- Small molecules and their controlled release that induce the osteogenic/chondrogenic commitment of stem cells.
- Chemical Constituents, Quality Control, and Bioactivity of Epimedii Folium (Yinyanghuo).
- Design, preparation, surface recognition properties, and characteristics of icariin molecularly imprinted polymers
- Local drug delivery for enhancing fracture healing in osteoporotic bone.
- Resveratrol Inhibits LPS-Induced MAPKs Activation via Activation of the Phosphatidylinositol 3-Kinase Pathway in Murine RAW 264.7 Macrophage Cells
- Effects and Interaction of Icariin, Curculigoside, and Berberine in Er-Xian Decoction, a Traditional Chinese Medicinal Formula, on Osteoclastic Bone Resorption
- Cyclic fluid shear stress promotes osteoblastic cells proliferation through ERK5 signaling pathway
- Response of human periodontal ligament cells to baicalin.
- Chemotypic and genetic diversity in Epimedium sagittatum from different geographical regions of China.
- Effects of compatibility of deproteinized antler cancellous bone with various bioactive factors on their osteogenic potential.
- Effects of icariin on the alkline phosphatase activity of human periodontal ligament cells inhibited by lipopolysaccharide.
- Effect of epimedium pubescen flavonoid on bone mineral status and bone turnover in male rats chronically exposed to cigarette smoke
- Icariin promotes bone formation via the BMP-2/Smad4 signal transduction pathway in the hFOB 1.19 human osteoblastic cell line.
- Solubility of Icariin in a Binary Solvent System of Ethanol and Water
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