Evidence for a new tumour suppressor locus (DBM) in human B–cell neoplasia telomeric to the retinoblastoma gene
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Summary
It is concluded that D13S25 lies close to a tumour suppressor locus whose inactivation contributes to the initiation or progression of low grade B–cell malignancy.
- Type
- article
- Published
- 1993-01-01
- Cited by
- 146
- References
- 30
- OpenAlex
- https://openalex.org/W2056163856
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:19923161
Keywords
Biology, Retinoblastoma, Locus (genetics), Suppressor, Genetics
References
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- The use of rat mixed-thymocyte culture-conditioned medium for hybridoma production, cloning and revival.
- Isolation of human chromosome 13-specific DNA sequences cloned from flow sorted chromosomes and potentially linked to the retinoblastoma locus.
- Structural alterations at the putative retinoblastoma locus in some human leukemias and preleukemia.
- Prognostic subgroups in B-cell chronic lymphocytic leukemia defined by specific chromosomal abnormalities.
- Tumor suppressor genes.
- An SspI RFLP at the D13S25 locus identified by the anonymous single copy probe H2-42.
- Abnormalities in structure and expression of the human retinoblastoma gene in SCLC.
- Prediction of the risk of hereditary retinoblastoma, using DNA polymorphisms within the retinoblastoma gene.
- Structural rearrangement of the retinoblastoma gene in human breast carcinoma.
- Report of the committee on the genetic constitution of chromosome 13.
- Hemizygous deletion of the 3' end of the RB1 gene in a case of Philadelphia positive-acute lymphoblastic leukemia.
Cited by
- Deletions of chromosome 13 in multiple myeloma identified by interphase FISH usually denote large deletions of the q arm or monosomy
- Molecular delineation of 13q deletion boundaries in 20 patients with myeloid malignancies.
- National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment.
- Deletion of 13q14.3 and not 13q12 is the most common genetic abnormality detected in chronic lymphocytic leukemia cells.
- The roles of microRNAs in tumorigenesis and angiogenesis.
- Increased number of chromosomal imbalances and high-level DNA amplifications in mantle cell lymphoma are associated with blastoid variants.
- Minimal region of loss at 13q14 in B-cell chronic lymphocytic leukemia.
- Analyse moléculaire du myélome : vers de nouvelles perspectives thérapeutiques
- Detailed molecular delineation of 13q14.3 loss in B-cell chronic lymphocytic leukemia.
- The search for genetic clues in chronic lymphocytic leukemia.
- Chromosome abnormalities and RB1 gene deletions in chronic lymphocytic leukemia.
- Distinct regions of allelic loss on 13q in prostate cancer.
- Comparison of loss of heterozygosity patterns in invasive low-grade and high-grade epithelial ovarian carcinomas.
- Detección de trisomia 12 en sindromes linfoproliferativos crónicos y reordenamiento BCR-ABL en leucemia mieloide crónica, mediante la técnica de hibridación in situ fluorescente
- Chromosome 13q deletion mapping in pituitary tumors: infrequent loss of the retinoblastoma susceptibility gene (RB1) locus despite loss of RB1 protein product in somatotrophinomas.
- Molecular cytogenetic delineation of deletions and translocations involving chromosome band 7q22 in myeloid leukemias.
- Chromosome 13q deletion mapping in head and neck squamous cell carcinomas: identification of two distinct regions of preferential loss.
- Allelic loss on chromosome 13q in human prostate carcinoma.
- Role of the retinoblastoma protein in the pathogenesis of human cancer.
- Abnormalities of chromosome bands 13q12 to 13q14 in childhood acute lymphoblastic leukemia.
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