cAMP with other signaling cues converges on Rac1 to stabilize the endothelial barrier— a signaling pathway compromised in inflammation
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Summary
New is the notion that the tight endothelial barrier under resting conditions is maintained by continuous cAMP formation induced by hormones such as epinephrine or by activation of Rac1 downstream of S1P that is secreted by erythrocytes and activated platelets.
- Type
- review
- Published
- 2014-03-01
- Cited by
- 94
- References
- 110
- OpenAlex
- https://openalex.org/W2056064770
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:17154022
Keywords
Cell biology, Rap1, RAC1, Adherens junction, Signal transduction
References
- Cross talk between paxillin and Rac is critical for mediation of barrier-protective effects by oxidized phospholipids.
- Sepsis and endothelial permeability.
- Myosin Light Chain Kinase Signaling in Endothelial Barrier Dysfunction
- Phosphodiesterase‐4 inhibition as a therapeutic approach to treat capillary leakage in systemic inflammation
- Regulation of the inflammatory response of vascular endothelial cells by EPAC1
- Hypoxia–reoxygenation‐induced endothelial barrier failure: role of RhoA, Rac1 and myosin light chain kinase
- Angiopoietin-1 protects the adult vasculature against plasma leakage
- Regulation of vascular endothelial barrier function by Epac, a cAMP-activated exchange factor for Rap GTPase.
- Differential regulation of endothelial cell permeability by high and low doses of oxidized 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphocholine.
- Rap-afadin axis in control of Rho signaling and endothelial barrier recovery
- Fragmented oxidation products define barrier disruptive endothelial cell response to OxPAPC
- Lipopolysaccharide attenuates mRNA levels of several adenylyl cyclase isoforms in vivo.
- Pharmacokinetics and Pharmacodynamics of Intravenous Inotropic Agents
- Sac-1004, a novel vascular leakage blocker, enhances endothelial barrier through the cAMP/Rac/cortactin pathway.
- Phosphodiesterase 4 inhibition attenuates plasma volume loss and transvascular exchange in volume‐expanded mice
- Sphingosine 1-phosphate signalling via the endothelial differentiation gene family of G-protein-coupled receptors.
- Ultrastructural analysis reveals cAMP-dependent enhancement of microvascular endothelial barrier functions via Rac1-mediated reorganization of intercellular junctions.
- Angiopoietin-1 Requires p190 RhoGAP to Protect against Vascular Leakage in Vivo*
- Erythrocytes store and release sphingosine 1‐phosphate in blood
- Angiopoietin-2 in patients requiring renal replacement therapy in the ICU: relation to acute kidney injury, multiple organ dysfunction syndrome and outcome
Cited by
- Activation of the Small GTPase Rap1 Inhibits Choroidal Neovascularization by Regulating Cell Junctions and ROS Generation in Rats
- Putting VE-cadherin into JAIL for junction remodeling
- Sepsis: neue Erkenntnisse, andere Perspektiven – neue Therapieoptionen?
- Adducin Is Involved in Endothelial Barrier Stabilization
- Glial cell line-derived neurotrophic factor promotes barrier maturation and wound healing in intestinal epithelial cells in vitro.
- PKA Compartmentalization via AKAP220 and AKAP12 Contributes to Endothelial Barrier Regulation
- Lactate transport and receptor actions in cerebral malaria
- Between sealing and leakiness: molecular dynamics of the endothelium to maintain and regulate barrier function
- Exendin-4 promotes endothelial barrier enhancement via PKA- and Epac1-dependent Rac1 activation.
- Pharmacological treatment of chronic pelvic ischemia
- The conflicting role of Rac1 in inflammation
- Soluble VE-cadherin is involved in endothelial barrier breakdown in systemic inflammation and sepsis.
- Platelet endothelial cell adhesion molecule‐1 (PECAM1) plays a critical role in the maintenance of human vascular endothelial barrier function
- Quantification of Malignant Breast Cancer Cell MDA-MB-231 Transmigration across Brain and Lung Microvascular Endothelium
- THE ENDOTHELIUM IN SEPSIS
- Cyclic AMP Sensor EPAC Proteins and Their Role in Cardiovascular Function and Disease.
- Phosphodiesterase 4 Inhibition Dose Dependently Stabilizes Microvascular Barrier Functions and Microcirculation in a Rodent Model of Polymicrobial Sepsis
- Activation of Vascular Endothelial Growth Factor (VEGF) Receptor 2 Mediates Endothelial Permeability Caused by Cyclic Stretch*
- RhoB controls endothelial barrier recovery by inhibiting Rac1 trafficking to the cell border
- Small GTPases and their guanine-nucleotide exchange factors and GTPase-activating proteins in neutrophil recruitment
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