Role of intracellular calcium and NADPH oxidase NOX5-S in acid-induced DNA damage in Barrett's cells and Barrett's esophageal adenocarcinoma cells.
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Summary
P pulsed acid treatment causes DNA damage via increase of intracellular calcium and activation of NOX5-S, thereby contributing to the progression from BE to EA.
- Type
- article
- Published
- 2014-05-15
- Cited by
- 25
- References
- 56
- OpenAlex
- https://openalex.org/W2055923058
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:26877458
Keywords
Intracellular, NADPH oxidase, Calcium in biology, Small interfering RNA, Chemistry
References
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Cited by
- Enzymatic regulation and functional relevance of NOX5
- Rational Design and Therapeutic Potential of a Novel Nox1 Inhibitor for the Treatment of Pulmonary Hypertension: In Vitro and In Vivo Effects of Nox1 Inhibition
- Evaluation of the Potential Effects of Nifedipine-induced DNA Damage and Micronucleus Formation in Female Mice and their Embryos
- Rho Kinase ROCK2 Mediates Acid-Induced NADPH Oxidase NOX5-S Expression in Human Esophageal Adenocarcinoma Cells
- Role of ion transporters in the bile acid-induced esophageal injury.
- Overview of major molecular alterations during progression from Barrett's esophagus to esophageal adenocarcinoma
- Bile acid receptor TGR5, NADPH Oxidase NOX5-S and CREB Mediate Bile Acid-Induced DNA Damage In Barrett’s Esophageal Adenocarcinoma Cells
- Redox signaling in the gastrointestinal tract.
- Slight hypercalcemia is not associated with positive responses in the Comet Assay in male rat liver.
- Activation of NADPH oxidases leads to DNA damage in esophageal cells
- The Molecular Regulation and Functional Roles of NOX5.
- Clinical Significance of NADPH Oxidase 5 in Human Colon Cancer
- Associations between the severity of reflux esophagitis in children and changes in oxidative stress, serum inflammation, vasoactive intestinal peptide and motilin
- The Effects of EGTA on the Quality of Fresh and Cryopreserved-Thawed Human Spermatozoa
- Effect of Proton Pump Inhibitor Therapy on NOX5, mPGES1 and iNOS expression in Barrett’s Esophagus
- Membranous NOX5-derived ROS oxidizes and activates local Src to promote malignancy of tumor cells
- Association of pepsin and DNA damage in laryngopharyngeal reflux-related vocal fold polyps.
- The Impact of Oxidative Stress in Human Pathology: Focus on Gastrointestinal Disorders
- Resolvin D1 attenuates acid-induced DNA damage in esophageal epithelial cells and rat models of acid reflux.
- Alterations in the Ca2+ toolkit in oesophageal adenocarcinoma
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