The Corticosteroid Receptor Hypothesis of Depression
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Summary
Mouse genetics, allowing for selective inactivation of genes relevant for HPA regulation and molecular pharmacology, dissecting the intracellular cascade of CR signaling, are the most promising future research fields, suited for identifying genes predisposing to depression.
- Type
- review
- Published
- 2000-11-01
- Cited by
- 2,226
- References
- 213
- Access
- Open access
- OpenAlex
- https://openalex.org/W2055747883
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:30009640
Keywords
Depression (economics), Antidepressant, Hormone, Endocrinology, Internal medicine
References
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- The Effects of a Switch-Off Response Accompanied by Hypothalamically Induced Restlessness on Immunoendocrinological Changes in Cats
- Common polymorphisms in the glucocorticoid receptor gene are associated with adrenocortical responses to psychosocial stress.
- Implication du BDNF dans l'étiopathogenèse et le traitement des troubles anxio-dépressifs : aspects précliniques.
- Synergistic interaction between ketoconazole and several antidepressant drugs with allopregnanolone treatments in ovariectomized Wistar rats forced to swim.
- Reduced hippocampal neurogenesis and number of hilar neurones in streptozotocin‐induced diabetic mice: reversion by antidepressant treatment
- Combined dexamethasone/corticotropin releasing hormone test predicts treatment response in major depression - a potential biomarker?
- Interferon-alpha-induced depressive symptoms are related to changes in the cytokine network but not to cortisol.
- Augmentation strategies for treatment‐resistant depression: a literature review
- Stress-induced changes in primate prefrontal profiles of gene expression
- Everything has rhythm: focus on glucocorticoid pulsatility.
- La stimulation du nerf vague pour le traitement de la dépression réfractaire : les résultats après un an de suivi
- Suppressive effect of mirtazapine on the HPA system in acutely depressed women seems to be transient and not related to antidepressant action.
- Impact of citalopram on the HPA system. A study of the combined DEX/CRH test in 30 unipolar depressed patients.
- Assessment of a multi-assay, serum-based biological diagnostic test for major depressive disorder: a Pilot and Replication Study
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- Stress, schizophrenia and bipolar disorder.
- Attenuation of hypothalamic-pituitary-adrenocortical hyperactivity in depressed patients by mirtazapine
- Effect of co-treatment with fluoxetine or mirtazapine and risperidone on the active behaviors and plasma corticosterone concentration in rats subjected to the forced swim test
- Epigenetic programming of neuroendocrine systems during early life
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