GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons.
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Summary
In embryonic midbrain cultures, recombinant human GDNF promoted the survival and morphological differentiation of dopaminergic neurons and increased their high-affinity dopamine uptake and did not increase total neuron or astrocyte numbers or transmitter uptake.
- Type
- letter
- Published
- 1993-05-21
- Cited by
- 3,281
- References
- 25
- OpenAlex
- https://openalex.org/W2054810445
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24694425
Keywords
Glial cell line-derived neurotrophic factor, GDNF family of ligands, Dopaminergic, Neurotrophic factors, Midbrain
References
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- Pituitary FSH is released by a heterodimer of the β-subunits from the two forms of inhibin
- Expression and characterization of recombinant human ciliary neurotrophic factor from Escherichia coli.
- The toxicity of MPTP to dopamine neurons in culture is reduced at high concentrations.
- Cortical astrocytes activated by basic fibroblast growth factor secrete molecules that stimulate differentiation of mesencephalic dopaminergic neurons
- Midbrain Dopaminergic Cell Loss in Parkinson's Disease and MPTP‐Induced Parkinsonism: Sparing of Calbindin‐D25k—Containing Cells a
- Basic fibroblast growth factor promotes the survival and development of mesencephalic neurons in culture.
- Recombinant human bone morphogenetic protein induces bone formation.
- Epidermal growth factor exerts neuronotrophic effects on dopaminergic and GABAergic CNS neurons: Comparison with basic fibroblast growth factor
- Clonal cell lines from the rat central nervous system
- Promotion of central cholinergic and dopaminergic neuron differentiation by brain-derived neurotrophic factor but not neurotrophin 3.
- Purification and properties of a type beta transforming growth factor from bovine kidney.
- Mesencephalic type I astrocytes mediate the survival of substantia nigra dopaminergic neurons in culture.
- Conditioned media derived from glial cell lines promote survival and differentiation of dopaminergic neurons in vitro: Role of mesencephalic glia
- Isolation of porcine follicular fluid inhibin of 32K daltons.
- In vitro maturation of mesencephalic dopaminergic neurons from mouse embryos is enhanced in presence of their striatal target cells.
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- Stem Cells—One of the Pathways for Nervous Tissue Regeneration
- New roles for glial cell line-derived neurotrophic factor and neurturin: involvement in hair cycle control.
- Brain-derived neurotrophic factor works coordinately with partner molecules to initiate tyrosine hydroxylase expression in striatal neurons.
- Bone morphogenetic proteins inhibit proliferation, induce reversible differentiation and prevent cell death in astrocyte lineage cells.
- The effect of acetylcholinesterase on outgrowth of dopaminergic neurons in organotypic slice culture of rat mid-brain
- Neurotrophic effects of amnion explants co-cultured with rat mesencephalon.
- Infusion of glial maturation factor-beta reduces behavioral deficits after caudate nucleus injury in rats.
- Neurturin, a relative of glial-cell-line-derived neurotrophic factor
- Glial cell line-derived neurotrophic factor attenuates the excitotoxin-induced behavioral and neurochemical deficits in a rodent model of Huntington's disease
- Growth/differentiation factor 5 protects nigrostriatal dopaminergic neurones in a rat model of Parkinson's disease.
- Modulation of Nigrostriatal Dopaminergic Transmission by Antisense Oligodeoxynucleotide Against Brain-Derived Neurotrophic Factor
- Cyclosporine A-Induced Hyperactivity in Rats: Is it Mediated by Immunosuppression, Neurotrophism, or Both?
- Induction of a midbrain dopaminergic phenotype in Nurr1-overexpressing neural stem cells by type 1 astrocytes
- Dopamine neurons in a simple GDNF-treated meso-striatal organotypic co-culture model
- The Intermolecular Disulfide Bridge of Human Glial Cell Line-Derived Neurotrophic Factor: Its Selective Reduction and Biological Activity of the Modified Protein
- Induction of glial cell line-derived neurotrophic factor and c-ret porto-oncogene-like immunoreactivity in rabbit spinal cord after transient ischemia.
- Neurturin is a neurotrophic factor for penile parasympathetic neurons in adult rat.
- Enhancement of survival of stored dopaminergic cells and promotion of graft survival by exposure of human fetal nigral tissue to glial cell line--derived neurotrophic factor in patients with Parkinson's disease. Report of two cases and technical considerations.
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