Enhanced Sarcoplasmic Reticulum Ca2+-leak and Increased Na+-Ca2+-Exchanger Function Underlie Delayed Afterdepolarizations in Patients with Chronic Atrial Fibrillation
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Summary
Enhanced SR Ca2+ leak through CaMKII-hyperphosphorylated RyR2, in combination with larger INCX for a given SR Ca 2+ release and increased diastolic [Ca2+]i-voltage coupling gain, causes AF-promoting atrial delayed afterdepolarizations/triggered activity in cAF patients.
- Type
- article
- Published
- 2012-03-28
- Cited by
- 609
- References
- 55
- Access
- Open access
- OpenAlex
- https://openalex.org/W2051822015
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11950897
Keywords
Afterdepolarization, Ryanodine receptor, Ryanodine receptor 2, Internal medicine, Calmodulin
References
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- Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice.
- Pharmacological evidence for altered src kinase regulation of ICa,L in patients with chronic atrial fibrillation
- The ryanodine receptor channel as a molecular motif in atrial fibrillation: pathophysiological and therapeutic implications.
- Role of IKur in Controlling Action Potential Shape and Contractility in the Human Atrium: Influence of Chronic Atrial Fibrillation
- Ca sparks do not explain all ryanodine receptor-mediated SR Ca leak in mouse ventricular myocytes.
- Stoichiometric phosphorylation of cardiac ryanodine receptor on serine 2809 by calmodulin-dependent kinase II and protein kinase A.
- Atrial L-type Ca2+ currents and human atrial fibrillation.
- Calcium Handling Abnormalities in Atrial Fibrillation as a Target for Innovative Therapeutics
- Programmed electrical stimulation in mice.
- Distinct contractile and molecular differences between two goat models of atrial dysfunction: AV block-induced atrial dilatation and atrial fibrillation.
- The role of sarcolemmal Ca2+‐ATPase in the regulation of resting calcium concentration in rat ventricular myocytes
- G-Protein beta(3)-subunit 825T allele is associated with enhanced human atrial inward rectifier potassium currents.
- So little source, so much sink: requirements for afterdepolarizations to propagate in tissue.
- Cardiac excitation–contraction coupling
Cited by
- Atrial remodeling and atrial fibrillation: recent advances and translational perspectives.
- Systems biology and cardiac arrhythmias
- Pleiotropic Effects of Antiarrhythmic Agents: Dronedarone in the Treatment of Atrial Fibrillation
- Emerging roles of junctophilin-2 in the heart and implications for cardiac diseases.
- Current controversies in determining the main mechanisms of atrial fibrillation
- The combined effects of ranolazine and dronedarone on human atrial and ventricular electrophysiology.
- Unique cardiomyocyte ultrastructure in atria: Role of T tubules in subcellular Ca2+ signaling and atrial arrhythmogenesis.
- Anticancer Therapy-Induced Atrial Fibrillation: Electrophysiology and Related Mechanisms
- CaMKII signaling in heart diseases: Emerging role in diabetic cardiomyopathy.
- Calcium handling and atrial fibrillation
- Chronic Exercise: A Contributing Factor to Atrial Fibrillation?
- Atrial fibrillation in the elderly: the potential contribution of reactive oxygen species
- Atrial fibrillation ablation: translating basic mechanistic insights to the patient.
- Neue Entwicklungen in der antiarrhythmischen Therapie des Vorhofflimmerns
- Fibrillation atriale : des mécanismes physiopathologiques à la prise en charge thérapeutique
- Atrial Fibrillation Activates AMP-Dependent Protein Kinase and its Regulation of Cellular Calcium Handling: Potential Role in Metabolic Adaptation and Prevention of Progression.
- Development of a biophysically detailed model of the human atria for the investigation of the mechanisms of atrial arrhythmias
- Expression and function of Kv1.1 potassium channels in human atria from patients with atrial fibrillation
- The role of CaMKII in diabetic heart dysfunction
- Cavβ2 transcription start site variants modulate calcium handling in newborn rat cardiomyocytes
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