Molecular genetics of adult acute myeloid leukemia: prognostic and therapeutic implications.
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Summary
Genetic findings in AML are reviewed to discuss their clinical implications and identify genome-wide expression signatures that separate cytogenetic and molecular subsets of patients with AML into previously unrecognized biologic and/or prognostic subgroups.
- Type
- review
- Published
- 2011-02-10
- Cited by
- 588
- References
- 80
- OpenAlex
- https://openalex.org/W2049722365
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:31506502
Keywords
Myeloid leukemia, Medicine, microRNA, Gene expression profiling, Gene
References
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- Use of gene-expression profiling to identify prognostic subclasses in adult acute myeloid leukemia.
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- MicroRNA miR-181a correlates with morphological sub-class of acute myeloid leukaemia and the expression of its target genes in global genome-wide analysis
Cited by
- Modelling chromosome missegregation in tumour evolution
- Impact of molecular prognostic factors in cytogenetically normal acute myeloid leukemia at diagnosis and relapse
- Acute myeloid leukaemia in adults.
- The evolving role of FLT3 inhibitors in acute myeloid leukemia: quizartinib and beyond
- Comparative value of post-remission treatment in cytogenetically normal AML subclassified by NPM1 and FLT3-ITD allelic ratio
- Novel Therapies for Acute Myeloid Leukemia: Are We Finally Breaking the Deadlock?
- Ten-year outcome of patients with acute myeloid leukemia not treated with allogeneic transplantation in first complete remission.
- Molecular genetic tests for FLT3, NPM1, and CEBPA in acute myeloid leukemia.
- Genome-Wide Analysis of Severe Congenital Neutropenia and Leukemia Implications for leukemogenesis
- Studies on CEBPA mutations in acute myeloid leukaemia
- To establish the role of mutations in c-KIT tyrosine kinase in the pathogenesis and therapy of core-binding factor-related acute myeloid leukaemia (AML)
- Bayesian Variable Selection in High-dimensional Applications
- The FLT3 Tyrosine Kinase in Leukemia : Deciphering the Downstream Signaling Events and Drug-Escape Mechanisms
- Gene expression deregulation in acute myeloid leukemia. Causes, consequences, and therapeutic relevance
- Homéostasie cellulaire du fer dans les cellules leucémiques myéloïdes
- Nucleophosmin 1, upregulated in adenomas and cancers of the colon, inhibits p53‐mediated cellular senescence
- Individualisierte Medizin in der Diagnostik und prognostischen Einschätzung in der akuten myeloischen Leukämie mit normalem Karyotyp bei Erwachsenen unter 65 Jahren: eine systematische Literaturrecherche und Metaanalyse zu FLT3-ITD
- NUP98‐NSD1 gene fusion and its related gene expression signature are strongly associated with a poor prognosis in pediatric acute myeloid leukemia
- Activity of the aurora kinase B inhibitor AZD1152 in acute myeloid leukaemia
- Multidrug resistance in relapsed AML: Evidence of biological heterogeneity
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