Manipulation of Kupffer cells by liposome encapsulated clodronate and propamidine—synergistic and antagonistic effects of liposomal phospholipids and drugs

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Summary

At certain drug concentrations, anionic liposomes are shown to be efficacious carriers for intraphagocytic delivery of clodronate, but not for propamidine, and omission of cholesterol or mannosylation of the phospholipid bilayers did not improve the efficacy when compared to neutral liposome.

Type
article
Published
1998-03-20
Cited by
6
References
24

Keywords

Liposome, Phosphatidylcholine, Chemistry, Phospholipid, Drug carrier

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