CpG motifs in bacterial DNA trigger direct B-cell activation

Keywords

CpG site, DNA, Oligonucleotide, Biology, Immune system

References

• Systemic Administration of a Phosphorothioate Oligonucleotide with a Sequence Complementary to p53 for Acute Myelogenous Leukemia and Myelodysplastic Syndrome: Initial Results of a Phase I TrialEliel Bayever, Patrick L. Iversen, Michael Bishop — 1993
• Comparison of Cellular Binding and Uptake of Antisense Phosphodiester, Phosphorothioate, and Mixed Phosphorothioate and Methylphosphonate OligonucleotidesQiuyan Zhao, Sara Matson, Charles Herrera — 1993
• A role for endogenous retroviral sequences in the regulation of lymphocyte activation.A M Krieg, William C. Gause, M F Gourley — 1989
• Development of the autoimmune B cell repertoire in MRL-lpr/lpr mice.D M Klinman, Robert A. Eisenberg, A D Steinberg — 1990
• Accumulation of guanine-cytosine-enriched low M.W. DNA fragments in lymphocytes of patients with systemic lupus erythematosus.Hirotake Sano, Minoru Imokawa, A D Steinberg — 1983
• Stimulation of in vitro murine lymphocyte proliferation by bacterial DNA.Joseph P. Messina, Gary S. Gilkeson, David S. Pisetsky — 1991
• Requirements of class II-mediated B cell differentiation for class II cross-linking and cyclic AMP.Gail A. Bishop — 1991
• Nonspecific Suppression of [3H]Thymidine Incorporation by "Control" OligonucleotidesSara Matson, Arthur Μ. Krieg — 1992
• Selection of Antisense Oligonucleotides on the Basis of Genomic Frequency of the Target SequenceJian Han, Zhou Zhu, Chuancheih Hsu — 1994
• Current concepts in antisense drug design.John F. Milligan, Mark D. Matteucci, John C. Martin — 1993
• DNA binding to human leukocytes. Evidence for a receptor-mediated association, internalization, and degradation of DNA.Robert M. Bennett, Gary Gabor, M Merritt — 1985
• Binding Properties of Human Anti‐DNA Antibodies to Cloned Human DNA FragmentsHiroshi Sano, Osamu Takai, Nobutoshi Harata — 1989
• Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis.Bruce Richardson, Lee Scheinbart, John R. Strahler — 1990
• Lymphocyte stimulation: a rapid multiparameter analysis.Zbigniew Darżynkiewicz, Frank Traganos, T Sharpless — 1976
• Gene inhibition using antisense oligodeoxynucleotidesRichard W. Wagner — 1994
• CpG islands as gene markers in the vertebrate nucleusAdrian Bird — 1987
• Applications of antisense oligodeoxynucleotides in immunology and autoimmunity researchArthur Μ. Krieg — 1992
• Subversion of the immune system by pathogens.Philippa Marrack, John W. Kappler — 1994
• Antisense oligodeoxynucleotide phosphorothioate complementary to Gag mRNA blocks replication of human immunodeficiency virus type 1 in human peripheral blood cells.Julianna Lisziewicz, Sun D, Frank Weichold — 1994
• Pervasive CpG suppression in animal mitochondrial genomes.Lon R. Cardon, C Burge, David A. Clayton — 1994

Cited by

• Vaccination of mice with MUC1 cDNA suppresses the development of lung metastasesMika Kamata, Kaori Denda‐Nagai, Nobuyoshi Kubota — 2004
• Estimation of the effective doses of nasal-inactivated influenza vaccine in humans from mouse-model experiments.Shinichi Tamura, Hideki Hasegawa, Takeshi Kurata — 2010
• CpG Still Rocks! Update on an Accidental DrugArthur Μ. Krieg — 2012
• Active and Passive Immunization Strategies for Protection of Mice and Monkeys Against Orthopoxvirus InfectionChristiana N. Fogg — 2006
• Phosphorothioate Oligodeoxynucleotides: Antisense or Anti-Protein?Magdalena Valenzuela Guzmán — 1995
• Liposomal targeting of bcl-2 antisense oligonucleotides with enhanced stability into human myeloma cell lines.Hanna Ollikainen, Katriina Lappalainen, Ilpo Jää Skeläinen — 1996
• Characterization and Modulation of Immune Stimulation by Modified OligonucleotidesMaría González‐González, José María Sayagués, Raquel Bartolomé-Casado — 1997
• Antisense oligonucleotides: is the glass half full or half empty?Krešimir Fertalj, Igor Nazor — 1998
• Interaction of human plasma membrane proteins and oligodeoxynucleotides.V. V. Gorev, A. S. Kingsep — 1998
• Activation of spleen lymphocytes by plasmid DNA.佳佑 阿久津, 志乃 岩下, V V Vlassov — 1999
• Differential expression and secretion of alpha 1 anti-trypsin between direct DNA injection and implantation of transfected myoblastSamira Bioubakhsh — 1999
• Synthetic oligodeoxynucleotides containing CpG motifs enhance immunogenicity of a peptide malaria vaccine in Aotus monkeys.Javier Rodríguez — 1999
• Plasmid DNA vaccines are effective in the absence of IFNgamma.Uriel Hernández‐Salinas, Aurelio Ramı́rez-Bautista — 1999
• Enhancement of antibody responses by DNA immunization using expression vectors mediating efficient antigen secretion.Domínguez Sanjurjo, María Ramona — 1999
• The Gordon Wilson Lecture: viruses and human disease.Gary J. Nabel — 2001
• CpG Oligonucleotides Are Potent Adjuvants for the Activation of Autoreactive Encephalitogenic T Cells In VivoJörg Rüpke — 2000
• Immune Cell Activation by Bacterial Cpg-DNA through Myeloid Differentiation Marker 88 and Tumor Necrosis Factor Receptor–Associated Factor (Traf)6R Mills — 2000
• CpG DNA: security code for host defenseJuan Calvo Vérgez — 2001
• Interleukin-12- and Gamma Interferon-Dependent Protection against Malaria Conferred by CpG Oligodeoxynucleotide in MiceLennart Asbach, Hardi Hungar, Michael Meyer zu Hörste — 2001
• Enhanced immune response to T-independent antigen by using CpG oligodeoxynucleotides encapsulated in liposomes.David Rubenson, Jerry Aroesty — 2001

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