MR relaxometry in Huntington's disease: correlation between imaging, genetic and clinical parameters.

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Summary

The observed T2/CAG covariations may reflect changes in levels and forms of iron: this suggests that HD patients with a higher genetic load have more ferritin-bound ("safe form") iron in the pallidum and/or more low-molecular ("toxic") ironIn the caudate may enable oxidative stress and thus underlie progression of the disease.

Type
article
Published
2007-12-15
Cited by
45
References
29

Keywords

Relaxometry, Correlation, Medicine, Huntington's disease, Nuclear magnetic resonance

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