MR relaxometry in Huntington's disease: correlation between imaging, genetic and clinical parameters.
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Summary
The observed T2/CAG covariations may reflect changes in levels and forms of iron: this suggests that HD patients with a higher genetic load have more ferritin-bound ("safe form") iron in the pallidum and/or more low-molecular ("toxic") ironIn the caudate may enable oxidative stress and thus underlie progression of the disease.
- Type
- article
- Published
- 2007-12-15
- Cited by
- 45
- References
- 29
- OpenAlex
- https://openalex.org/W2047298395
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:33017192
Keywords
Relaxometry, Correlation, Medicine, Huntington's disease, Nuclear magnetic resonance
References
- MRI evaluation of basal ganglia ferritin iron and neurotoxicity in Alzheimer's and Huntingon's disease.
- The quantitative Relation Between T1‐Weighted and T2‐Weighted MRI of Normal gray Matter and iron concentration
- MR evaluation of brain iron in children with cerebral infarction.
- MR relaxometry and 1H MR spectroscopy for the determination of iron and metabolite concentrations in PKAN patients
- Iron alters glutamate secretion by regulating cytosolic aconitase activity.
- Chronic liver disease: relaxometry in the brain after liver transplantation
- THE EFFECT OF AGE ON THE NON‐HAEMIN IRON IN THE HUMAN BRAIN
- Evidence for more widespread cerebral pathology in early HD
- In vivo evidence of cerebellar atrophy and cerebral white matter loss in Huntington disease
- Increased basal ganglia iron levels in Huntington disease.
- The relation between brain iron and NMR relaxation times: An in vitro study
- White Matter Volume and Cognitive Dysfunction in Early Huntington's Disease
- Huntingtin: a single bait hooks many species.
- Frequency dependence of MR relaxation times I. Paramagnetic ions
- MRI of brain iron.
- Selective neurodegeneration in Huntington's disease
- Dearth of glutamate transporters contributes to striatal excitotoxicity.
- The oxidant stress hypothesis in Parkinson's disease: Evidence supporting it
- A new polymerase chain reaction (PCR) assay for the trinucleotide repeat that is unstable and expanded on Huntington's disease chromosomes.
- Neuropathological Classification of Huntington's Disease
Cited by
- Imaging of iron.
- The role of iron in gray matter degeneration in Huntington's disease: A magnetic resonance imaging study
- Iron quantification of microbleeds in postmortem brain
- pH as a Biomarker of Neurodegeneration in Huntington's Disease: A Translational Rodent-Human MRS Study
- Correlations of Behavioral Deficits with Brain Pathology Assessed through Longitudinal MRI and Histopathology in the R6/2 Mouse Model of HD
- T2 relaxometry measurements in low spatial frequency brain regions differ between fast spin-echo and multiple-echo spin-echo sequences
- Complex Relationships between Cerebral Blood Flow and Brain Atrophy in Early Huntington’s Disease
- Elevated brain iron is independent from atrophy in Huntington's Disease
- Quantification of punctate iron sources using magnetic resonance phase
- A complementary diffusion tensor imaging (DTI)-histological study in a model of Huntington's disease.
- Iron dysregulation in Huntington's disease
- Clustering of atlas-defined cortical regions based on relaxation times and proton density
- MRI T2 Hypointensities in basal ganglia of premanifest Huntington's disease
- Iron dysregulation in movement disorders.
- Texture analysis of ultrahigh field T2*‐weighted MR images of the brain: Application to Huntington's disease
- Development of biomarkers for Huntington's disease.
- Seeking huntington disease biomarkers by multimodal, cross‐sectional basal ganglia imaging
- In vivo iron quantification in collagenase‐induced microbleeds in rat brain
- Iron accumulation in the basal ganglia in Huntington's disease: cross-sectional data from the IMAGE-HD study
- G06 Iron defect is implicated in white matter changes in Huntington disease
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