The cardiovascular and pharmacokinetic profile of dofetilide in conscious telemetered beagle dogs and cynomolgus monkeys
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Summary
The effects of dofetilide were studied in monkeys and dogs to compare effects relative to human exposure and to demonstrate the importance of knowing the carrier and removal status of canine coronavirus.
- Type
- article
- Published
- 2008-08-01
- Cited by
- 35
- References
- 31
- Access
- Open access
- OpenAlex
- https://openalex.org/W2045710012
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:22843746
Keywords
Dofetilide, Beagle, Pharmacokinetics, Medicine, QT interval
References
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- Characterization of the inhibitory effects of erythromycin and clarithromycin on the HERG potassium channel
- Significance of metabolism in the disposition and action of the antidysrhythmic drug, dofetilide. In vitro studies and correlation with in vivo data.
- Pharmacokinetic and pharmacodynamic modeling of the effects of oral and intravenous administrations of dofetilide on ventricular repolarization
- QT prolongation and fatal arrhythmias: a review of clinical implications and effects of drugs.
- Pharmacokinetics of a series of bis(methanesulphonamido-arylalkyl)amines in the beagle dog.
- Dose-response relation between terfenadine (Seldane) and the QTc interval on the scalar electrocardiogram: distinguishing a drug effect from spontaneous variability.
- Pharmacodynamics and Pharmacokinetics of the Class III Antiarrhythmic Agent Dofetilide (UK‐68,798) in Humans
- Dofetilide, A Novel Class III Antiarrhythmic Agent
- The Analysis of Variance
- Non-clinical evaluation of ventricular repolarization (ICH S7B): results of an interim survey of international pharmaceutical companies.
- Assessing predictors of drug-induced torsade de pointes.
- Accumulation of drugs by resting or beating cardiac tissue.
- QT interval prolongation by non-cardiovascular drugs: issues and solutions for novel drug development.
- Effect of a single oral dose of moxifloxacin (400 mg and 800 mg) on ventricular repolarization in healthy subjects
- Rate-corrected QT interval: techniques and limitations.
Cited by
- An introduction to QT interval prolongation and non‐clinical approaches to assessing and reducing risk
- Effects of telemetric epicardial leads and ventricular catheters on arrhythmia incidence in cynomolgus monkeys.
- Evaluation of electrocardiograms recorded in cynomolgus monkeys with short- and long-term intracardiac lead implantations.
- Interventricular dispersion in repolarization causes bifid T waves in dogs with dofetilide-induced long QT syndrome.
- Measuring the risk of torsades de pointes: electrocardiographic evaluation of PNU-142093 in conscious cynomolgus non-human primates using restraint and non-restraint procedures.
- Comprehensive analysis of cardiac arrhythmias in telemetered cynomolgus monkeys over a 6 month period.
- A step towards characterisation of electrophysiological profile of torsadogenic drugs.
- Assessment of the pharmacological effects of inotropic drugs on left ventricular pressure and contractility: an evaluation of the QA interval as an indirect indicator of cardiac inotropism.
- Comprehensive arrhythmia analysis in telemetered non-human primates
- Characterization of an anesthetized dog model of transient cardiac ischemia and rapid pacing: a pilot study for preclinical assessment of the potential for proarrhythmic risk of novel drug candidates.
- The T wave: physiology and pathophysiology
- Surface-patterned SU-8 cantilever arrays for preliminary screening of cardiac toxicity.
- Vascular flow reserve as a link between long‐term blood pressure level and physical performance capacity in mammals
- Sodium and Water Homeostasis
- The effect of tachycardic irregularity on ventricular repolarization dynamics
- Characterizing QT interval prolongation in early clinical development: a case study with methadone
- Proliferative Role of Kv11 Channels in Murine Arteries
- Have the Findings from Clinical Risk Prediction and Trials Any Key Messages for Safety Pharmacology?
- Does mean arterial blood pressure scale with body mass in mammals? Effects of measurement of blood pressure
- Comparison of one- and three-lead ECG to measure cardiac intervals and differentiate drug-induced multi-channel block.
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