Age-dependent Defect in Vascular Endothelial Growth Factor Expression Is Associated with Reduced Hypoxia-inducible Factor 1 Activity*

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Summary

It is proposed that age-dependent reduction in hypoxia-induced VEGF expression results from reduced HIF-1 activity and may explain the previously described age- dependent impairment of angiogenesis in response to ischemia.

Type
article
Published
2000-09-22
Cited by
309
References
38
Access
Open access

Keywords

Hypoxia (environmental), Vascular endothelial growth factor, Hypoxia-Inducible Factor 1, Vascular endothelial growth factor A, Cell biology

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