Age-dependent Defect in Vascular Endothelial Growth Factor Expression Is Associated with Reduced Hypoxia-inducible Factor 1 Activity*
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Summary
It is proposed that age-dependent reduction in hypoxia-induced VEGF expression results from reduced HIF-1 activity and may explain the previously described age- dependent impairment of angiogenesis in response to ischemia.
- Type
- article
- Published
- 2000-09-22
- Cited by
- 309
- References
- 38
- Access
- Open access
- OpenAlex
- https://openalex.org/W2044857579
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11342065
Keywords
Hypoxia (environmental), Vascular endothelial growth factor, Hypoxia-Inducible Factor 1, Vascular endothelial growth factor A, Cell biology
References
- Upregulation of vascular endothelial growth factor expression induced by myocardial ischaemia: implications for coronary angiogenesis.
- Stabilization of vascular endothelial growth factor mRNA by hypoxia and hypoglycemia and coregulation with other ischemia-induced genes
- Transcription Factors and Aging
- Similarities between the oxygen-sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin.
- Rat-liver superoxide dismutase. Purification and age-related modifications.
- Gene expression profile of aging and its retardation by caloric restriction.
- Erythropoietin: a model system for studying oxygen-dependent gene regulation.
- Activation of Hypoxia-inducible Transcription Factor Depends Primarily upon Redox-sensitive Stabilization of Its α Subunit*
- Hypoxic induction of vascular endothelial growth factor (VEGF) in human epithelial cells is mediated by increases in mRNA stability
- Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes.
- Hypoxia-induced Transcriptional Activation and Increased mRNA Stability of Vascular Endothelial Growth Factor in C6 Glioma Cells (*)
- Decreased erythropoietin responsiveness to iron deficiency anemia in the elderly
- Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1*
- Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
- Regulation of the Hypoxia-inducible Transcription Factor 1α by the Ubiquitin-Proteasome Pathway*
- The function of hypoxia‐inducible factor 1 (HIF‐1) is impaired in senescent mice
- Transcriptional Regulation of the Rat Vascular Endothelial Growth Factor Gene by Hypoxia (*)
- Post-transcriptional Regulation of Vascular Endothelial Growth Factor by Hypoxia (*)
- Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
- Hypoxia-inducible Protein Binding to Vascular Endothelial Growth Factor mRNA and Its Modulation by the von Hippel-Lindau Protein*
Cited by
- Physiologie du compartiment endothélial circulant dans l’hypertension artérielle pulmonaire et perspectives de développement d’un produit de thérapie cellulaire
- Aging-associated changes in vascular activity: a potential link to geriatric cardiovascular disease.
- Impact of Lifestyle Factors on Vascular Aging
- Post-natal endothelial progenitor cells for neovascularization in tissue regeneration.
- Age-dependent depression in circulating endothelial progenitor cells in patients undergoing coronary artery bypass grafting.
- Vascular cell senescence and vascular aging.
- Sarcopenia: Aging-Related Loss of Muscle Mass and Function.
- Circulating progenitor cells in atrial fibrillation: Relationship to endothelial dysfunction, thrombogenesis and inflammation
- Aging of progenitor cells: limitation for regenerative capacity?
- Stem cell biology for vascular regeneration.
- РОЛЬ КОМПОНЕНТОВ СЕКРЕТОМА, АССОЦИИРОВАННОГО СО СТАРЕНИЕМ, В РАЗВИТИИ ИНСУЛИНОРЕЗИСТЕНТНОСТИ МУЛЬТИПОТЕНТНЫХ СТРОМАЛЬНЫХ КЛЕТОК ЖИРОВОЙ ТКАНИ
- Endothelial progenitor cells: pathogenetic role and therapeutic perspectives.
- Healing of elderly patients with diabetic foot ulcers, venous stasis ulcers, and pressure ulcers.
- Oxygen Transport To Tissue XXIII
- Angiogenesis and cardiovascular disease
- Hypoxia-inducible factor-1alpha accumulation in the rat brain in response to hypoxia and ischemia is attenuated during aging.
- The Age-Related Morphological Changes in the Capillary Architecture of the Peripheral Nerve in Rats
- The Dual Role of HIF Hydroxylase PHD3 in Cancer Cell Survival
- Age is no barrier to muscle structural, biochemical and angiogenic adaptations to training up to 24 months in female rats
- Standard clinical practice underestimates the role and significance of erythropoietin deficiency in sickle cell disease
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