The Selective Inhibition of Serotonin‐ Induced Contractions of Rabbit Cerebral Vascular Smooth Muscle by Calcium‐ Antagonistic Dihydropyridines: An Investigation of the Mechanism of Action of Nimodipine
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Summary
It is postulated that the selective inhibition of the sustained tonic contraction of the basilar artery is due to a selective inhibition by nimodipine of calcium movement through ROCs in this vessel.
- Type
- article
- Published
- 1981-05-01
- Cited by
- 204
- References
- 29
- Access
- Open access
- OpenAlex
- https://openalex.org/W2041184529
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:6885513
Keywords
Nimodipine, Basilar artery, Calcium, Chemistry, Serotonin
References
- Mechanisms of action of transmitters and other substances on smooth muscle.
- The action of vasodilating drugs on isolated basilar, coronary and mesenteric arteries of the dog.
- A comparison of the inhibitory effect of cinnarizine and papaverine on the noradrenaline- and calcium-evoked contraction of isolated rabbit aorta and mesenteric arteries.
- Cerebral arterial spasm: part 9. In vitro effects of nifedipine on serotonin-, phenylephrine-, and potassium-induced contractions of canine basilar and femoral arteries.
- Provocative Testing with Ergonovine to Evaluate the Efficacy of Treatment with Calcium Antagonists in Variant Angina
- Calcium antagonists and contractile responses in rat vas deferens and guinea pig ileal smooth muscle.
- INHIBITION BY Cd2+, VERAPAMIL AND PAPAVERINE OF Ca2+‐INDUCED CONTRACTIONS IN ISOLATED CEREBRAL AND PERIPHERAL ARTERIES OF THE DOG
- Effects of some vasodilators on calcium translocation in intact and fractionated vascular smooth muscle.
- Aetiology of cerebral arterial spasm following subarachnoid haemorrhage: evidence against a major involvement of 5-hydroxy-tryptamine in the production of acute spasm.
- Cerebral arterial spasm: part 10. Reversal of acute and chronic spasm in dogs with orally administered nifedipine.
- Evidence for Greater Susceptibility of Isolated Dog Cerebral Arteries to Ca Antagonists than Peripheral Arteries
- Specific pharmacology of calcium in myocardium, cardiac pacemakers, and vascular smooth muscle.
- Differential effects of calcium removal upon vascular smooth muscle contraction induced by norepinephrine, histamine and potassium.
- Electromechanical and pharmacomechanical coupling in vascular smooth muscle.
- The voltage- and time-dependent effects of (-)-verapamil on the slow inward current in isolated cat ventricular myocardium.
- Influence of initial tension and changes in sensitivity during amine-induced contractions of pial arteries in vitro.
- Effect of a calcium antagonist on experimental constriction of human brain vessels.
- Alterations in high and low affinity binding of 45Ca in rabbit aortic smooth muscle by norepinephrine and potassium after exposure to lanthanum and low temperature.
- Vascular smooth muscle. II. Pharmacology of normal and hypotensive vessels.
- Calcium, Calcium Translocation, and Specific Calcium Antagonists
Cited by
- Actions of some prostaglandins and leukotrienes on rat cerebral and mesenteric arteries.
- Clinical Trial of Nimodipine for Single Attacks of Classic Migraine
- Calcium antagonist and the peripheral circulation: differences and similarities between PY 108–068, nicardipine, verapamil and diltiazem
- A comparative study of the pharmacodynamic effects of nimodipine and nifedipine in the isolated spontaneously beating rabbit heart.
- Effects of dotarizine on 45Ca2+ movements and contractile responses in vascular smooth muscle.
- Cerebrovascular and cerebral effects of nimodipine--an update.
- Effect of nimodipine on mitochondrial respiration in different rat brain areas after subarachnoid haemorrhage.
- Identification of Calcium Channels with Radiolabelled Calcium Blockers
- Proceedings of the 8th European Congress of Neurosurgery, Barcelona, September 6–11, 1987
- Ion Channels and Ion Pumps
- Cardiovascular Effects of Dihydropyridine-Type Calcium Antagonists and Agonists
- Calcium Entry Blockers in Cardiovascular and Cerebral Dysfunctions
- Factors involved in the physiological regulation of the cerebral circulation.
- Drugs for Heart Disease
- Dihydropyridine calcium agonist and antagonist effects on aldosterone secretion.
- Nimodipine Has an Inhibitory Action on Neurotransmitter Release from Human Cerebral Arteries
- Calcium channel blocking activity: Screening methods for plant derived compounds.
- Some extracardiac effects of diltiazem and other calcium entry blockers.
- Modulation of calcium channel function by drugs.
- Structural and functional changes in cerebral arteries from spontaneously hypertensive rats.
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