Immunopathology of post kala‐azar dermal leishmaniasis (PKDL): T‐cell phenotypes and cytokine profile
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Summary
The results indicate that PKDL develops as a result of an influx of immunocompetent cells into skin, which harbours parasites, and the inflammatory response to the parasites is complex.
- Type
- article
- Published
- 1999-12-01
- Cited by
- 78
- References
- 24
- OpenAlex
- https://openalex.org/W2040479272
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:43634091
Keywords
Leishmania donovani, Immunology, Peripheral blood mononuclear cell, Cytokine, Visceral leishmaniasis
References
- In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha.
- A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
- Endemic kala-azar in eastern Sudan: a longitudinal study on the incidence of clinical and subclinical infection and post-kala-azar dermal leishmaniasis.
- Post kala-azar dermal leishmaniasis in the Sudan: clinical features, pathology and treatment.
- Evidence of subjects sensitized to Leishmania infantum on the French Mediterranean coast: differences in gamma interferon production between this population and visceral leishmaniasis patients
- The contrasting roles of CD4+ T cells in intracellular infections in humans: leishmaniasis as an example.
- Production of interferon-gamma and interleukin-4 by human T cells recognizing Leishmania lipophosphoglycan-associated protein.
- Identification of Leishmania donovani using a polymerase chain reaction in patient and animal material obtained from an area of endemic kala-azar in the Sudan.
- Leishmania donovani: long-term culture of axenic amastigotes at 37 degrees C.
- Detection and characterization of Leishmania in tissues of patients with post kala-azar dermal leishmaniasis using a specific monoclonal antibody.
- Activation of Human T Lymphocytes by Leishmania Lipophosphoglycan
- Dichotomy of the human T cell response to Leishmania antigens. I. Th1‐like response to Leishmania major promastigote antigens in individuals recovered from cutaneous leishmaniasis
- Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies.
- Transient depletion of T cells with high LFA‐1 expression from peripheral circulation during acute Plasmodium falciparum malaria
- Interleukin 10 and interferon gamma regulation of experimental Trypanosoma cruzi infection
- Dichotomy of the T cell response to Leishmania antigens in patients suffering from cutaneous leishmaniasis; absence or scarcity of Th1 activity is associated with severe infections
- Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.
- Direct agglutination test for diagnosis and sero-epidemiological survey of kala-azar in the Sudan.
- High levels of plasma IL‐10 and expression of IL‐10 by keratinocytes during visceral leishmaniasis predict subsequent development of post‐kala‐azar dermal leishmaniasis
- Endemic kala-azar in eastern Sudan: post-kala-azar dermal leishmaniasis.
Cited by
- Immune privilege in sites of chronic infection: Leishmania and regulatory T cells
- Post‐kala‐azar dermal leishmaniasis and borderline tuberculoid leprosy
- Miltefosine effectively modulates the cytokine milieu in Indian post kala-azar dermal leishmaniasis.
- Differential Regulation of miRNA Profiles of Human Cells Experimentally Infected by Leishmania donovani Isolated From Indian Visceral Leishmaniasis and Post-Kala-Azar Dermal Leishmaniasis
- PKDL--a drug related phenomenon?
- Antileishmanial Drugs: search for t SIR2 inhibitors
- Immune Regulation during Chronic Visceral Leishmaniasis
- IL-10- and TGF-β-Mediated Susceptibility in Kala-azar and Post-kala-azar Dermal Leishmaniasis: The Significance of Amphotericin B in the Control of Leishmania donovani Infection in India1
- Present status of antileishmanial vaccines
- Dermoid cyst with magnetic resonance image of sack‐of‐marbles
- Post‐kala‐azar dermal leishmaniasis – an overview
- IL-27 regulates IL-10 and IL-17 from CD4+ cells in non-healing Leishmania major infection
- Post kala-azar dermal leishmaniasis: an unresolved mystery
- CD4+CD25−Foxp3− Th1 cells are the source of IL-10–mediated immune suppression in chronic cutaneous leishmaniasis
- Development of a semi-automated colorimetric assay for screening anti-leishmanial agents.
- Re‐examination of the immunosuppressive mechanisms mediating non‐cure of Leishmania infection in mice
- Evidence for Involvement of Th17 Type Responses in Post Kala Azar Dermal Leishmaniasis (PKDL)
- Enhanced lesional Foxp3 expression and peripheral anergic lymphocytes indicate a role for regulatory T cells in Indian post-kala-azar dermal leishmaniasis.
- Cytokine-producing T cell subsets in human leishmaniasis.
- Immunochemotherapy of persistent post-kala-azar dermal leishmaniasis: a novel approach to treatment.
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