Non-viral vectors for gene-based therapy
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Summary
The biological barriers to gene delivery in vivo are introduced and recent advances in material sciences, nanotechnology and nucleic acid chemistry that have yielded promising non-viral delivery systems are discussed, some of which are currently undergoing testing in clinical trials.
- Type
- review
- Published
- 2014-07-15
- Cited by
- 2,875
- References
- 170
- OpenAlex
- https://openalex.org/W2039551908
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:15273455
Keywords
Genetic enhancement, Nucleic acid, Oligonucleotide, Biology, Gene delivery
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Cited by
- Assembling Mn:ZnSe quantum dots-siRNA nanoplexes for gene silencing in tumor cells.
- Mixing-sequence-dependent nucleic acid complexation and gene transfer efficiency by polyethylenimine.
- Flexible DNA junction assisted efficient construction of stable gene nanoparticles for gene delivery.
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- Gene editing technology as an approach to the treatment of liver diseases
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- mRNA Polyplexes with Post-Conjugated GALA Peptides Efficiently Target, Transfect, and Activate Antigen Presenting Cells
- Ultrasensitive SERS detection of highly homologous miRNAs by generating 3D organic-nanoclusters and a functionalized chip with locked nucleic acid probes.
- Mechanisms of Unprimed and Dexamethasone-Primed Nonviral Gene Delivery to Human Mesenchymal Stem Cells
- Ruthenium-containing supramolecular nanoparticles based on bipyridine-modified cyclodextrin and adamantyl PEI with DNA condensation properties
- Recent progress in nanomaterials for nucleic acid delivery in cancer immunotherapy.
- Musculoskeletal tissue engineering: Regional gene therapy for bone repair.
- Recent progress of non-linear topological structure polymers: synthesis, and gene delivery
- Electrostatic nucleic acid nanoassembly enables hybridization chain reaction in living cells for ultrasensitive mRNA imaging.
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