Preoperative radiation with concurrent chemotherapy for resectable rectal cancer: effect of dose escalation on pathologic complete response, local recurrence-free survival, disease-free survival, and overall survival.
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Summary
A statistically significant increase in LRFS, DFS, and OS was seen with radiation doses of 46Gy and greater, but there was no difference between 46 Gy and 50 Gy, and all treatment schedules were well tolerated.
- Type
- article
- Published
- 2006-03-01
- Cited by
- 112
- References
- 27
- OpenAlex
- https://openalex.org/W2036595545
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:33729814
Keywords
Medicine, Radiation therapy, Clinical endpoint, Toxicity, Chemotherapy
References
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Cited by
- Phase I trial of preoperative hypofractionated intensity-modulated radiotherapy with incorporated boost and oral capecitabine in locally advanced rectal cancer.
- Volumetric modulated arc therapy with simultaneous integrated boost for locally advanced rectal cancer.
- Future directions in combined modality therapy for rectal cancer: reevaluating the role of total mesorectal excision after chemoradiotherapy
- Comment augmenter la réponse complète au traitement néo-adjuvant ?
- Locally Advanced Rectal Cancer
- Aims of combined modality therapy in rectal cancer (M0).
- QoL de doentes com cancro do recto localmente avançado: QRT pré-operatória
- Rectal cancer : Are we ready for a paradigm shift?
- Tratamiento neoadyuvante en cáncer de recto: comparación de esquemas de radioquimioterapia
- Phase I trial of the combination of the Akt inhibitor nelfinavir and chemoradiation for locally advanced rectal cancer.
- A Phase II Trial of Preoperative Chemoradiotherapy with Oral DPD-Inhibitory Fluoropyrimidines in Patients with Advanced Rectal Cancer
- FDG-PET-CT reduces the interobserver variability in rectal tumor delineation.
- Racial and ethnic disparities in outcomes with radiation therapy for rectal adenocarcinoma
- Experiences of Preoperative Only Radiotherapy in Patients with Non-Metastasising Rectal Tumours
- Preoperative treatment with capecitabine, bevacizumab and radiotherapy for primary locally advanced rectal cancer--a two stage phase II clinical trial.
- Long-Term Oncologic Results and Complications After Preoperative Chemoradiotherapy for Rectal Cancer: A Single-Institution Experience After a Median Follow-Up of 95 Months
- Impact of Time Duration After Neoadjuvant Therapy to Surgery on Response and Outcome in Rectal Cancer Patients
- Effectiveness of Image-Guided Radiotherapy for Locally Advanced Rectal Cancer
- Rectum‐conserving surgery in the era of chemoradiotherapy
- Preoperative endorectal brachytherapy in the treatment of locally advanced rectal cancer: Rethinking neoadjuvant treatment
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