Liposome- or LDL-administered Zn (II)-phthalocyanine as a photodynamic agent for tumours. I. Pharmacokinetic properties and phototherapeutic efficiency.
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Summary
It is found that Zn-Pc doses as low as 0.07-0.35 mg kg-1 are sufficient for inducing an efficient tumour response that is linearly dependent on the injected dose, and PDT gives satisfactory results even if performed at relatively long time intervals after administration.
- Type
- article
- Published
- 1990-03-01
- Cited by
- 154
- References
- 27
- Access
- Open access
- OpenAlex
- https://openalex.org/W2035571401
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:1226203
Keywords
Liposome, Pharmacokinetics, Fibrosarcoma, Photodynamic therapy, Chemistry
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- In vitro interaction of the photoactive anticancer porphyrin derivative photofrin II with low density lipoprotein, and its delivery to cultured human fibroblasts
- ULTRASTRUCTURAL STUDIES ON THE MECHANISM OF THE PHOTODYNAMIC THERAPY OF TUMORS
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- TUMOR LOCALIZATION AND PHOTOSENSITIZATION BY SULFONATED DERIVATIVES OF TETRAPHENYLPORPHINE
Cited by
- Comparative pharmacokinetic and photodynamic studies with zinc(II) phthalocyanine in hamsters bearing an induced or transplanted rhabdomyosarcoma.
- Steady state and time-resolved spectroscopic studies on zinc(II) phthalocyanine in liposomes.
- Effect of the delivery system on the biodistribution of Ge(IV) octabutoxy-phthalocyanines in tumour-bearing mice.
- Apoptosis of mouse MS-2 fibrosarcoma cells induced by photodynamic therapy with Zn (II)-phthalocyanine.
- Determination of the in vivo pharmacokinetics of palladium-bacteriopheophorbide (WST09) in EMT6 tumour-bearing Balb/c mice using graphite furnace atomic absorption spectroscopy
- Possibilités et limites des traitements endoscopique et photodynamique pour le carcinome épidermoïde précoce des voies aérodigestives supérieures, des bronches et de ľœsophage
- [Delivery of photosensitizers for photodynamic therapy].
- Enhancing photodynamic therapy of refractory solid cancers : Combining second-generation photosensitizers with multi-targeted liposomal delivery
- New Trends in Photobiology (Invited Review) The role of the low density lipoprotein receptor pathway in the delivery of lipophilic photosensitizers in the photodynamic therapy of tumours
- Photodamage Induced by Zinc(II)‐phthalocyanine to Microtubules, Actin, α‐Actinin and Keratin of HeLa Cells ¶
- Local photodynamic therapy with Zn(II)-phthalocyanine in an experimental model of intimal hyperplasia.
- PEG‐coated Poly(lactic acid) Nanoparticles for the Delivery of Hexadecafluoro Zinc Phthalocyanine to EMT‐6 Mouse Mammary Tumours
- Factors controlling the selectivity and efficiency of tumour damage in photodynamic therapy
- Synthesis and biological evaluation of Foscan® bile acid conjugates to target esophageal cancer cells.
- State of the art in the delivery of photosensitizers for photodynamic therapy.
- A fluorescence quenching study on protoporphyrin IX in a model membrane system.
- Photobleaching studies on azabenzoporphyrins and related systems: a comparison of the photobleaching of the zinc(II) complexes of the tetrabenzoporphyrin, 5-azadibenzo[b,g]porphyrin and phthalocyanine systems
- Tumour-localising and -photosensitizing properties of liposome-delivered Ge(IV)-octabutoxy-phthalocyanine.
- The distribution of the tumour photosensitizers Zn(II)-phthalocyanine and Sn(IV)-etiopurpurin among rabbit plasma proteins.
- A COMPARISON OF FLUORESCENCE METHODS USED IN THE PHARMACOKINETIC STUDIES OF Zn(II)PHTHALOCYANINE IN MICE
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