A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma
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Summary
It is suggested that apoptosis inhibition may be a general feature of neoplasia and survivin is identified as a potential new target for apoptosis-based therapy in cancer and lymphoma.
- Type
- article
- Published
- 1997-08-01
- Cited by
- 3,343
- References
- 23
- OpenAlex
- https://openalex.org/W2035523654
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:3062648
Keywords
Survivin, Inhibitor of apoptosis, Cancer research, Apoptosis, Programmed cell death
References
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- Apoptosis in the pathogenesis and treatment of disease
- Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors.
- The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins.
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- Bcl-2 and the regulation of programmed cell death
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- Characterization of an endogenous RNA transcript with homology to the antisense strand of the human c-myc gene.
- Tandem genes and clustered genes.
- Interleukin‐3 and Bcl‐2 cooperatively inhibit etoposide‐induced apoptosis in a murine pre‐B cell line
Cited by
- Role of the Survivin gene in pathophysiology.
- Molecular Biology of Human Herpesvirus 8: Novel Functions and Virus–Host Interactions Implicated in Viral Pathogenesis and Replication
- Characterization of a Small Molecule Smac Mimetic's Role in Inducing Apoptosis in Human Cancer Cells
- Programmed Cell Death in C. elegans
- Cell Division Regulation by BIR1, a Member of the Inhibitor of Apoptosis Family in Yeast*
- XIAP Regulates DNA Damage-induced Apoptosis Downstream of Caspase-9 Cleavage*
- Translational upregulation of X-linked inhibitor of apoptosis (XIAP) increases resistance to radiation induced cell death
- Survivin expression correlates with apoptosis resistance after lymphocyte activation and is found preferentially in memory T cells.
- Survivin is expressed on CD40 stimulation and interfaces proliferation and apoptosis in B-cell chronic lymphocytic leukemia.
- The Survivin saga goes in vivo.
- Effects of survivin antagonists on growth of established tumors and B7-1 immunogene therapy.
- Cloning and characterization of a proliferation-associated cytokine-inducible protein, CIP29.
- Significance of endothelial cell survival programs for renal transplantation.
- Inhibitor of apoptosis proteins and ovarian dysfunction in galactosemic rats
- Quantitative analysis of survivin mRNA expression in urine and tumor tissue of bladder cancer patients and its potential relevance for disease detection and prognosis
- Nuclear and cytoplasmic expression of survivin in 67 surgically resected pancreatic cancer patients
- Expression of survivin and of antigen detected by a novel monoclonal antibody, T332, is associated with outcome of diffuse large B‐cell lymphoma and its subtypes
- Molecular cloning and bioinformatics analysis of a novel spliced variant of survivin from human breast cancer cells
- Survivin, a cancer target with an emerging role in normal adult tissues
- Survivin expression is associated with bladder cancer presence, stage, progression, and mortality.
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- Survivin: A Bifunctional Inhibitor of Apoptosis Protein
- Advances in research on Survivin ,the inhibitor of apoptosis in cancer diagnosis and therapy
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- Oxidized Low Density Lipoprotein Induced Endothelial Cell Apoptosis via Survivin Down‐Regulation