The double-strand-break repair model for recombination.
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Summary
This work proposes a new mechanism for meiotic recombination, in which events are initiated by double-strand breaks that are enlarged to double- Strand gaps, and postmeiotic segregation can result from heteroduplex DNA formed at the boundaries of the gap-repair region.
- Type
- review
- Published
- 1983-05-01
- Cited by
- 2,428
- References
- 46
- OpenAlex
- https://openalex.org/W2034252391
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:39590123
Keywords
Heteroduplex, Gene conversion, Homologous recombination, Biology, Recombination
References
- Control of Cell Type in Saccharomyces cerevisiae: Mating Type and Mating-type Interconversion
- Effects of the RAD52 Gene on Recombination in SACCHAROMYCES CEREVISIAE.
- Genetic recombination : thinking about it in phage and fungi
- Mechanisms of Meiotic Gene Conversion, or “Wanderings on a Foreign Strand”
- Genetic Recombination: Understanding the Mechanisms
- Homothallic mating type switching generates lethal chromosome breaks in rad52 strains of Saccharomyces cerevisiae
- Evidence for meiotic recombination in Ascobolus involving only one member of a tetrad.
- Existence of homogeneous categories of mutants exhibiting various conversion patterns in gene 75 of Ascobolus immersus.
- The Utilization during Mitotic Cell Division of Loci Controlling Meiotic Recombination and Disjunction in DROSOPHILA MELANOGASTER.
- The suppression of gene conversion and intragenic crossing over in Ascobolus immersus: evidence for modifiers acting in the heterozygous state.
- A mechanism of DNA transposition.
- Gene conversion between duplicated genetic elements in yeast
- Evidence for a physical interaction between the transposed and the substituted sequences during mating type gene transposition in yeast.
- Isolation and characterisation of a yeast chromosomal replicator
- Meiotic gene conversion: a signal of the basic recombination event in yeast.
- Yeast transformation: a model system for the study of recombination.
- A general model for genetic recombination.
- Isolation of a circular derivative of yeast chromosome III: implications for the mechanism of mating type interconversion.
- Disparity of gene conversion in frameshift mutants located in locus b2 of Ascobolus immersus.
- Transformation of yeast.
Cited by
- Connections between RNA splicing and DNA intron mobility in yeast mitochondria: RNA maturase and DNA endonuclease switching experiments
- Induced crossing-over in Drosophila melanogaster germ cells of DNA repair-proficient and repair-deficient (mei-9L1) males following larval feeding with 5-azacytidine and mitomycin C.
- Characterization of double-strand break-induced recombination: homology requirements and single-stranded DNA formation
- A site-specific endonuclease and co-conversion of flanking exons associated with the mobile td intron of phage T4.
- Protein engineering by cDNA recombination in yeasts: shuffling of mammalian cytochrome P-450 functions.
- Selection of in vivo deletions in Saccharomyces cerevisiae
- The inheritance of epigenetic defects.
- Factors affecting levels of genetic diversity in natural populations.
- The REC46 gene of Saccharomyces cerevisiae controls mitotic chromosomal stability, recombination and sporulation: cell-type and life cycle stage-specific expression of the rec46-1 mutation
- Conformational isomerization of the Holliday junction associated with a cruciform during branch migration in supercoiled plasmid DNA.
- Different type of hepatitis B virus (HBV) DNA integrants that may reflect the integration process
- A recombination-based transgenic mouse system for genotoxicity testing.
- RAD1 and RAD10, but not other excision repair genes, are required for double-strand break-induced recombination in Saccharomyces cerevisiae
- Effects of DNA topoisomerase inhibitors on nonhomologous and homologous recombination in mammalian cells.
- Meiotic sister chromatid cohesion and recombination in two filamentous fungi
- Salmonella typhi contains identical intervening sequences in all seven rrl genes
- Abortive gap repair: underlying mechanism for Ds element formation
- Possible role of immunoglobulin recombination sequences in the genesis of variant t(2;8) translocations of Burkitt lymphoma.
- Targeted disruption of mouse long-chain acyl-CoA dehydrogenase gene reveals crucial roles for fatty acid oxidation.
- DNA hydrolysis and genome editing applications of GIY-YIG family homing endonucleases
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