Molecular Mechanisms Underlying the Analgesic Property of Intrathecal Dexmedetomidine and Its Neurotoxicity Evaluation: An In Vivo and In Vitro Experimental Study
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Summary
In vivo studies showed that intrathecalDEX has no significant pathological impacts on the spinal cord, and in vitro experiments indicated that DEX has potential protective effects of lidocaine-induced neural cell death.
- Type
- article
- Published
- 2013-02-07
- Cited by
- 88
- References
- 31
- Access
- Open access
- OpenAlex
- https://openalex.org/W2033675602
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11170352
Keywords
Neuropathic pain, Neurotoxicity, Spinal cord, Medicine, Dexmedetomidine
References
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- α2‐Adrenoceptor action on cell proliferation and mammary tumour growth in mice
- Dexmedetomidine provides cortical neuroprotection: impact on anaesthetic‐induced neuroapoptosis in the rat developing brain
- Lidocaine Induces Apoptosis via the Mitochondrial Pathway Independently of Death Receptor Signaling
- Dexmedetomidine Increases Hippocampal Phosphorylated Extracellular Signal–regulated Protein Kinase 1 and 2 Content by an α2-Adrenoceptor–independent Mechanism: Evidence for the Involvement of Imidazoline I1 Receptors
- Chronic inflammation and estradiol interact through MAPK activation to affect TMJ nociceptive processing by trigeminal caudalis neurons
- TGFβ1 Treatment Reduces Hippocampal Damage, Spontaneous Recurrent Seizures, and Learning Memory Deficits in Pilocarpine-Treated Rats
- Acid Solution Is a Suitable Medium for Introducing QX-314 into Nociceptors through TRPV1 Channels to Produce Sensory-Specific Analgesic Effects
- QX-314 Produces Long-lasting Local Anesthesia Modulated by Transient Receptor Potential Vanilloid Receptors in Mice
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- Use of dexmedetomidine for pain control
- The efficacy and neurotoxicity of dexmedetomidine administered via the epidural route
- KST5468, a new T-type calcium channel antagonist, has an antinociceptive effect on inflammatory and neuropathic pain models.
- EphrinBs/EphBs Signaling Is Involved in Modulation of Spinal Nociceptive Processing through a Mitogen-activated Protein Kinases-dependent Mechanism
Cited by
- Neurotoxicity Questions Regarding Common Peripheral Nerve Block Adjuvants in Combination with Local Anesthetics
- Dexmedetomidine prevents post-ischemic LTP via presynaptic and postsynaptic mechanisms.
- Dexmedetomidine Attenuates Blood-Spinal Cord Barrier Disruption Induced by Spinal Cord Ischemia Reperfusion Injury in Rats
- Comparison of caudal bupivacaine alone with bupivacaine plus two doses of dexmedetomidine for postoperative analgesia in pediatric patients undergoing infra‐umbilical surgery: a randomized controlled double‐blinded study
- Local Anesthetic Peripheral Nerve Block Adjuvants for Prolongation of Analgesia: A Systematic Qualitative Review
- Intraoperative Dexmedetomidine Promotes Postoperative Analgesia in Patients After Abdominal Colectomy
- Caudal dexmedetomidine decreases the required concentration of levobupivacaine for caudal block in pediatric patients: a randomized trial
- Involvement of spinal microglia and interleukin-18 in the anti-nociceptive effect of dexmedetomidine in rats subjected to CCI.
- Dexmedetomidine pretreatment alleviates propofol injection pain
- Alpha2-adrenoceptor-independent inhibition of acetylcholine receptor channel and sodium channel by dexmedetomidine in rat superior cervical ganglion neurons.
- Spinal anesthesia in children: A review
- Analgesic effect and adverse events of dexmedetomidine as additive for pediatric caudal anesthesia: a meta‐analysis
- Systemic dexmedetomidine augments inhibitory synaptic transmission in the superficial dorsal horn through activation of descending noradrenergic control: an in vivo patch-clamp analysis of analgesic mechanisms
- Co‐application of lidocaine and QX‐572 induces divergent pain behaviours in mice
- Inhibiting Spinal Neuron-Astrocytic Activation Correlates with Synergistic Analgesia of Dexmedetomidine and Ropivacaine
- Molecular targets and mechanism of action of dexmedetomidine in treatment of ischemia/reperfusion injury.
- Efficacy of dexmedetomidine as an adjuvant in paravertebral block in breast cancer surgery
- Epidural Co-Administration of Dexmedetomidine and Levobupivacaine Improves the Gastrointestinal Motility Function after Colonic Resection in Comparison to Co-Administration of Morphine and Levobupivacaine
- Intrathecal SB366791 Prevents Spinal EphrinB1/EphB1 Signaling Activation-induced Acute Thermal Hyperalgesia
- Intrathecal Dexmedetomidine and Fentanyl as Adjuvant to Bupivacaine on Duration of Spinal Block in Addicted Patients
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