Expression of Fyn, a non-receptor tyrosine kinase in prefrontal cortex from patients with schizophrenia and its correlation with clinical onset.
Explore this paper's citation graph
Summary
The results suggest that an increase in Fyn expression may contribute to the pathophysiology of schizophrenia.
- Type
- article
- Published
- 2003-04-10
- Cited by
- 31
- References
- 24
- OpenAlex
- https://openalex.org/W2033080891
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:45064182
Keywords
FYN, Biology, Schizophrenia (object-oriented programming), Messenger RNA, Tyrosine kinase
References
- Negative schizophrenic symptomatology and the PCP (phencyclidine) model of schizophrenia.
- A Unique Role for Fyn in CNS Myelination
- Nerve injury enhances rat neuronal glutamate transporter expression: identification by differential display PCR
- NMDA receptor regulation by Src kinase signalling in excitatory synaptic transmission and plasticity.
- Gene expression of PSD95 in prefrontal cortex and hippocampus in schizophrenia
- A magnetic resonance imaging study in first‐episode disorganized‐type patients with schizophrenia
- Brain morphology in first-episode schizophrenic-like psychotic patients: a quantitative magnetic resonance imaging study.
- Quantitative autoradiographic analysis of glutamate binding sites in the hippocampal formation in normal and schizophrenic brain post mortem.
- Reduced striatal spine size in schizophrenia: a postmortem ultrastructural study
- Schizophrenia: a disorder of neurodevelopment?
- Development of the Prefrontal Cortex during Adolescence: Insights into Vulnerable Neural Circuits in Schizophrenia
- Increased density of glutamate-immunoreactive vertical processes in superficial laminae in cingulate cortex of schizophrenic brain.
- Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia
- Expression of the human excitatory amino acid transporter 2 and metabotropic glutamate receptors 3 and 5 in the prefrontal cortex from normal individuals and patients with schizophrenia.
- Overexpression of Fyn tyrosine kinase causes abnormal development of primary sensory neurons in Xenopus laevis embryos
- Increased fearfulness of Fyn tyrosine kinase deficient mice.
- Regional neuropathology in schizophrenia: where are we? Where are we going?
- Measurement of GABAergic parameters in the prefrontal cortex in schizophrenia: focus on GABA content, GABA(A) receptor alpha-1 subunit messenger RNA and human GABA transporter-1 (HGAT-1) messenger RNA expression.
- Specific expressions of Fyn and Lyn, lymphocyte antigen receptor-associated tyrosine kinases, in the central nervous system.
- Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice.
Cited by
- FYN Kinase Gene: Another Glutamatergic Gene Associated with Bipolar Disorder?
- Badania genów kandydujących związanych z neurorozwojową hipotezą jadłowstrętu psychicznego z uwzględnieniem cech neuropsychologicznych oraz cech osobowości
- Modulation of schizophrenia-related genes in the forebrain of adolescent and adult rats exposed to maternal immune activation
- No genetic association between postsynaptic density-95 gene polymorphisms and schizophrenia.
- Glutathione deficit impairs myelin maturation: relevance for white matter integrity in schizophrenia patients
- No genetic association between Fyn kinase gene polymorphisms (-93A/G, IVS10+37T/C and Ex12+894T/G) and Japanese sporadic Alzheimer's disease.
- Viral infection, inflammation and schizophrenia
- Aberrant regulation of alternative pre-mRNA splicing in schizophrenia.
- Neuregulin 1 and schizophrenia
- Failure to support a genetic contribution of AKT1 polymorphisms and altered AKT signaling in schizophrenia
- Polymorphisms of the Fyn kinase gene and a performance on the Wisconsin Card Sorting Test in schizophrenia
- Hypothesis: Minimal changes in neural transmission in schizophrenia: Decreased glutamatergic and GABAergic functions in the prefrontal cortex
- RNA metabolism and dysmyelination in schizophrenia.
- Candidate genes, pathways and mechanisms for alcoholism: an expanded convergent functional genomics approach
- Increased plasma glutamate by antipsychotic medication and its relationship to glutaminase 1 and 2 genotypes in schizophrenia -- Juntendo University Schizophrenia Projects (JUSP).
- Significance of NMDA receptor-related glutamatergic amino acid levels in peripheral blood of patients with schizophrenia.
- The viral theory of schizophrenia revisited: Abnormal placental gene expression and structural changes with lack of evidence of H1N1 viral presence in placentae of infected mice or brains of exposed offspring
- No genetic association between polymorphisms in the Fyn kinase gene and age of schizophrenic onset.
- Decreased expression of Fyn protein and disbalanced alternative splicing patterns in platelets from patients with schizophrenia.
- Long homopurine•homopyrimidine sequences are characteristic of genes expressed in brain and the pseudoautosomal region
Related papers
- Protein tyrosine kinase activity in T lymphocytes from patients with systemic lupus erythematosus.
- Fyn kinase in brain diseases and cancer: the search for inhibitors.
- Altered splicing in hematological malignancies reveals a tissue-specific translational block of the Src-family tyrosine kinase fyn brain isoform expression
- Biochemical Basis for the Requirement of Kinase Activity for Cbl-dependent Ubiquitinylation and Degradation of a Target Tyrosine Kinase*
- Differential effect of Fyn tyrosine kinase deletion on offensive and defensive aggression.
- The Role of Astrocytes in the Central Nervous System: Physiological and Pathophysiological Conditions
- Mice lacking protein tyrosine kinase fyn develop a T helper-type 1 response and resistLeishmania major infection
- fyn tyrosine kinase is involved in keratinocyte differentiation control.
- Roles of the Src Tyrosine Kinases Lck and Fyn in Regulating γδTCR Signal Strength