Methylation of exon 2 of p16 is associated with late stage oesophageal cancer.
Explore this paper's citation graph
Summary
It is concluded that the methylation of exon 2 of p16 may have effects on the progression of oesophageal tumours that are independent of the expression of the p16 protein.
- Type
- article
- Published
- 2000-03-13
- Cited by
- 22
- References
- 16
- OpenAlex
- https://openalex.org/W2032980961
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:44766195
Keywords
Exon, Methylation, Biology, Cancer research, Molecular biology
References
- 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers
- Methylation, a major mechanism of p16/CDKN2 gene inactivation in head and neck squamous carcinoma.
- Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B.
- p16INK4a promoter is hypermethylated at a high frequency in esophageal adenocarcinomas.
- Polynucleotide kinase exchange reaction: quantitave assay for restriction endonuclease-generated 5'-phosphoroyl termini in DNA.
- Splicing into senescence: the curious case of p16 and p19ARF.
- Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF.
- Cancer Cell Cycles
- A quantitative HpaII-PCR assay to measure methylation of DNA from a small number of cells.
- Methylation of the 5' CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing.
- Hypermethylation of the CDKN2/p16 promoter during neoplastic progression in Barrett's esophagus.
- Role of the p16 tumor suppressor gene in cancer.
- Cell cycle-related gene abnormalities and product expression in esophageal carcinoma.
- The MTS1 gene is frequently mutated in primary human esophageal tumors.
- Transgene detection in mouse tail digests.
- Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame
Cited by
- Predicting Neoplastic Progression in Barrett's Esophagus
- p53, p16 and Fhit proteins expressions in chronic esophagitis and Chagas disease.
- A systematic review of hypermethylation of p16 gene in esophageal cancer
- Methylation and mutation analysis of p16 gene in gastric cancer.
- DNA promoter hypermethylation of p16 and APC predicts neoplastic progression in Barrett’s esophagus
- Restriction enzymes in the analysis of genetic alterations responsible for cancer progression
- The Methylation Patterns of a Disintegrin and Metalloproteinase 33 Gene (ADAM33) in Adult Asthma
- Nonrandom Intragenic Variations in Patterns of Codon Bias Implicate a Sequential Interplay Between Transitional Genetic Drift and Functional Amino Acid Selection
- p16(MTS-1/CDKN2/INK4a) in cancer progression.
- Early Diagnostic Biomarkers for Esophageal Adenocarcinoma—The Current State of Play
- Hypermethylation of Adenomatosis Polyposis Coli-2 and its Tumor Suppressor Role in Retinoblastoma
- High frequency of CDKN2A alterations in esophageal squamous cell carcinoma from a high‐risk Chinese population
- Methylation of the tumor suppressor gene p16 in gynecological carcinosarcoma
- Inactivation of the CDKN2/pl6 gene induced by methylation at 5′-CpG Island and its relation to lung cancer
- Hypermethylation of CDKN2A exon 2 in tumor, tumor-adjacent and tumor-distant tissues from breast cancer patients
- Expression, deletion [was deleton] and mutation of p16 gene in human gastric cancer.
- The hypermethylation of p16 gene exon 1 and exon 2: potential biomarkers for colorectal cancer and are associated with cancer pathological staging
- HPV-16 E6 and E7 expression drives transcription of p14(ARF) and p16(INK4a) prior to Intragenic methylation of CDKN2A.
- Discovering the mechanism and involvement of the methylation of cyclin-dependent kinase inhibitor 2A (CDKN2A) gene and its special locus region in gastric cancer
- DNA Methylation and Transcript Variant Analysis of CDKN2A Exon 2 Despite High Sequence Identity with CDKN2B Exon 2
Related papers
- Changes of DNA methylation of Isoetes sinensis under Pb and Cd stress
- Global methylation profiles in DNA from different blood cell types
- Effects of Particulate Matter on Genomic DNA Methylation Content and iNOS Promoter Methylation
- Progressive age-dependent DNA methylation changes start before adulthood in mouse tissues.
- New DNA methylation markers and global DNA hypomethylation are associated with oral cancer development
- Predicting the progress of colon cancer by DNA methylation markers of the p16 gene in feces - Evidence from an animal model
- Seasonality Modifies Methylation Profiles in Healthy People
- Characteristics of DNA methylation changes induced by traffic-related air pollution.
- Methylation of Migraine-Related Genes in Different Tissues of the Rat