Development and characterization of protein-loaded poly(lactide-co-glycolide) nanospheres
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Summary
Poly(lactide-co-glycolide) nanospheres designed to deliver proteins for extended periods of time are developed and can be proposed as new controlled release protein delivery systems.
- Type
- article
- Published
- 1997-06-01
- Cited by
- 264
- References
- 21
- OpenAlex
- https://openalex.org/W2032896288
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:96202625
Keywords
Poloxamer, Copolymer, PLGA, Emulsion, Chemistry
References
- Biodegradable submicron carriers for peptide drugs : Preparation of DL-lactide/glycolide copolymer(PLGA)nanospheres with nafarelin acetate by a novel emulsion-phase separation method in an oil system.
- Polylactide Microparticles Prepared by Double Emulsion-Evaporation: II. Effect of the Poly(Lactide-co-Glycolide) Composition on the Stability of the Primary and Secondary Emulsions
- Continuous release of proteins from biodegradable microcapsules and in vivo evaluation of their potential as a vaccine adjuvant
- Controlled vaccine release in the gut-associated lymphoid tissues. I. Orally administered biodegradable microspheres target the peyer's patches
- The preparation, characterization and pre-clinical evaluation of an orally administered HIV-I vaccine, consisting of a branched peptide immunogen entrapped in controlled release microparticles
- A comparison of alternative methods for the determination of the levels of proteins entrapped in poly(lactide-co-glycolide) microparticles
- Parameters affecting the immunogenicity of microencapsulated tetanus toxoid.
- Microparticulate absorption from the rat intestine
- Effect of the emulsion stability on the morphology and porosity of semicrystalline poly l-lactide microparticles prepared by w/o/w double emulsion-evaporation
- The preparation and characterization ofpoly(lactide-co-glycolide) microparticles: III. Microparticle/polymer degradation rates and the in vitro release of a model protein
- Characterization of V3 BRU peptide-loaded small PLGA microspheres prepared by a (w1/o)w2 emulsion solvent evaporation method
- Nanosphere and microsphere uptake via Peyer's patches: observation of the rate of uptake in the rat after a single oral dose
- Immune Response to Nasal Delivery of Antigenically Intact Tetanus Toxoid Associated with Poly(l‐lactic acid) Microspheres in Rats, Rabbits and Guinea‐pigs
- Biodegradable microspheres as controlled-release tetanus toxoid delivery systems.
- Cholera toxin B subunit (CTB) entrapped in microparticles shows comparable immunogenicity to CTB mixed with whole cholera toxin following oral immunization
- Quality improvement of spray-dried, protein-loaded D,L-PLA microspheres by appropriate polymer solvent selection.
- The Uptake and Translocation of Latex Nanospheres and Microspheres after Oral Administration to Rats
- Nanoparticle Uptake by the Rat Gastrointestinal Mucosa: Quantitation and Particle Size Dependency
- Injectable Biodegradable Microspheres for Vaccine Delivery
- Stability of Proteins and Their Delivery from Biodegradable Polymer Microspheres
Cited by
- Preparation and antibacterial activity evaluation of rifampicin-loaded poly lactide-co-glycolide nanoparticles.
- Desarrollo de nuevos vehículos para la administración de vacunas genéticas
- Quantifying drug release from PLGA nanoparticulates.
- Propylene carbonate quantification by its derivative 3,5-diacetyl-1,4-dihydro-2,6-lutidine.
- Exploring the follicular route for transcutaneous vaccination using nanoparticles
- Nanosphères polymères à couverture de hyaluronate pour la délivrance ciblée de molécules actives dans le traitement des affections du cartilage
- Methods and models for the investigation ofthe uptake of nanoparticles into hair follicles
- Nanoengineering of vaccines using natural polysaccharides
- Developing oral formulations for protein and peptide drugs
- Élaboration d’un système de libération contrôlée des facteurs de croissance FGF-2 et TGF-β1 en vue de leur utilisation en odontologie conservatrice et endodontie
- Stealth PLA-PEG Nanoparticles as Protein Carriers for Nasal Administration
- Comparative Uptake Studies of Bioadhesive and Non-Bioadhesive Nanoparticles in Human Intestinal Cell Lines and Rats: The Effect of Mucus on Particle Adsorption and Transport
- Polymeric nanomaterials – synthesis, functionalization and applications in diagnosis and therapy
- Nanotecnología Farmacéutica: Una galénica emergente
- Differentiation of embryonic stem cells through controlled release of growth factors from microspheres
- Protein Instability in Poly(Lactic-co-Glycolic Acid) Microparticles
- Apatite-polymer composites for the controlled delivery of bone morphogenetic proteins
- Loading of Tetanus Toxoid to Biodegradable Nanoparticles from Branched Poly(Sulfobutyl-Polyvinyl Alcohol)-g-(Lactide-Co-Glycolide) Nanoparticles by Protein Adsorption: A Mechanistic Study
- Composite gelatin delivery system for bone regeneration
- RETRACTED ARTICLE: Chrysin-loaded PLGA-PEG nanoparticles designed for enhanced effect on the breast cancer cell line
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